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… already had a fermentation process with already engineered strains, but this was to further build on those to try and … and so my team, we were responsible for coming up with new strains and new process improvements and new ways to recover … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …

… analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the delineation of … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et … al. (2015) Microbial species delineation using whole genome sequences. Nucleic Acids Res. 43(14):6761-71 Kyrpides NC et …

… through end-to-end automation, and further advancing sequence applications, single cell genomics, DNA synthesis, …

… tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … tells you what some of those design rules might be and constrains hypotheses that you can test about how to put things …

… and Environmental Research (BER) program, set the final sequence allocation for this program. …

… the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals …

… comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … and fungal metabolism necessary to design communities, new strains, or enzymes to convert plant biomass components into … basis of their behavior in the environment.  The JGI genome sequences and metabolomes of microbes and microbial …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … that is often done, where we’re really just looking at DNA sequences, and we don’t always know necessarily or pay … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … get made fun of by my now-wife, because she was wondering why it is that we needed to produce more toxins in the lab …