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… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … – how bacteria or other organisms communicate and how and why secondary metabolites are being produced in the … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… our User Program’s Community Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium … To meet these needs, the JGI deploys state-of-the-art sequencers and platforms dedicated to biodesign, single-cell …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … of infectious or inflammatory disease and these same species are being used not just by one generation but by …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … favorite examples of a secondary metabolite producer, and why they produce those metabolites? MARC: Well, I’m really …

… metabolites all refer to the chemicals that make species unique and different from one another. They are …

… We focus our efforts on integrating database mining and sequence design with scaling the production of large, … developing methods for converting digital information from sequence databases into biotechnological or environmental …

… I request a culture/slant/DNA of an organism that has been sequenced at the JGI? …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other …

… tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …