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DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … – how bacteria or other organisms communicate and how and why secondary metabolites are being produced in the … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … between chemistry and sequence to get anywhere. Like that’s why I say the more you know, the more you know because it …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Department of … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … Whole genome sequence of the denitrifying thermophile Geobacillus thermodenitrificans subsp. calidus DSM 22629T. M …

The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … are capable of making those strange ring systems. JACKIE: Why? Is it just because of ring strain or is it-- I guess, …

The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of … of fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and … resource hub that provides access to publicly available sequenced algal genomes and genome annotations generated by …

… able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … biology perspective, like if you have a cluster of genes, why can’t you just engineer you know, a promoter or an …