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… to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting some conversations … been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … with. So transformation, or manipulation of the DNA of genes and bacteria, occurred much faster earlier than they …

… secondary metabolites are produced by groups of genes known as biosynthetic gene clusters (BGCs.) As … more than 13 million BGCs in the catalog at the time of publication, it is the largest repository of BGC sequence data from over 1.3 million publicly available bacterial and archaeal genome and contig sources.  The …

… in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their … diversity and metabolic potential, with implications for energy production, environmental sustainability, and … linked to custom interfaces and visualization tools for user analysis. Additionally, the Program works to link …

… can use to integrate large genetic payloads directly into diverse microbes. Combining CRAGE with CRISPR provides … pest control. Secondary metabolites are highly regulated in bacteria, making it difficult to identify which pathway … because it allows researchers to delete or activate certain genes and assess how these edits affect functionality.  …

… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … Initially, my group really focused on marine actinobacteria. Then we moved into marine proteobacteria. Not a … you can make in the future is only getting more and more diverse as we move forward. But will it replace petroleum …

… Genomics group attempts to address this question in natural soil ecosystems by combining metagenomics with other omics … metagenomics and metatranscriptomics provide invaluable information on virus diversity and activity in microbial … resources. The main focus of these resource development efforts currently include:  in silico host prediction for …

… The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique opportunity for researchers to request the capabilities and expertise of … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS call with EMSL begin with a Letter of …

… about natural products and the science and scientists of secondary metabolism. Natural products, secondary metabolites, and specialized metabolites all refer to the … JGI acts on its goals in — and builds out its capabilities for — secondary metabolism research, “Natural Prodcast” …

… Our lab is using mass spectrometry based metabolite profiling to provide direct biochemical datasets … interest is understanding the distributed and dynamic metabolite networks of environmental microbes and how they transform their environment. Research Team    …

… bioenergy solutions.  The program has been a pioneering effort in functional genomics since 2012, with a focus on … cutting-edge research in synthetic biology by synthesizing genes, pathways, and whole chromosomes for bioenergy and bioproduct applications. The program has …

… vast diversity of fungi and algae to unlock their potential for bioenergy, environmental sustainability, and … The program’s focus is on large-scale sequencing efforts that survey the vast phylogenetic and ecological … labs and culture collections to produce hundreds of diverse algal genomes, which will be made accessible through …

… years, has been to bring generalizable technologies to bacteria, yeasts and algae previously with little to no … can be chromosomally integrated into a taxonomically diverse suite of microbial chassis strains for elevated opportunity for expression. Research Team    …