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… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no … found out all kinds of weird things. Glucose is toxic to a large number of marine bacteria. Do you believe that? I …

… … DAN UDWARY: Hey everyone and welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell … tell us what’s active, which peak is active before we even scale up. The reason that we did that was to fit what we … active in a heterologous host. So what you really need is a large tool kit of pieces in order to put them together to …

Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary … resource, but also yielding and supporting many high-impact publications ,” emphasized Markus Göker, who managed the …

… it’s a result of an evolutionary process that has led into large chemical diversity because the function relates to the … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great … product biosynthetic enzymes. ” And CORASON, for large-scale comparisons of biosynthetic gene clusters: “ A …

… — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required by the DOE for all work performed in its User Facilities, is … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and you can see that different Frankia have different size genomes depending on what kinds of plants, and what kinds of … derivatives of natural products.  ALISON: Like such a large diversity can have similar effects, I think is also …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS … samples of the spatial, temporal, taxonomic (environmental, microbial, plants, invertebrate, and vertebrate), and …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … that year that the Pacific Northwest had experienced the largest bloom ever observed on planet Earth. This was the … use our science to connect to problems that are on global scales. So I think that’s one area of science that we’re …

… convert sequence into functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for … dedicated to user project design, assembly, and quality control Strain Engineering Group : a research & development … automations for DNA design, assembly and analysis Overview of synthesis products The JGI DNA Synthesis platform enables …

Metagenomic datasets could help map out microbial diversity hotspots Over the past few decades, … in sequencing technologies have led to an abundance of microbial genomes becoming available to the global … to these challenges.  DOE’s Office of Science is the largest supporter of basic research in the physical sciences …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … anything to use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And … visual person. So, when we make genetic mutants in a fungal isolate, I can see something right away, and that’s exciting …

The JGI Project Management Office carries out a number of activities to facilitate … that all work performed in its User Facilities be covered by the User Agreement. … PMO: Frequently Asked Questions … … Tijana Glavina del Rio Metagenomics         Danielle Graham Microbial Program Nancy Hammon Workflow Planning Manager …