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You Can Move, But You Can’t Hide
… to replicate themselves and spread from cell to cell. Two of the most common forms of MGEs are viruses and plasmids. … like viruses and plasmids drive microbial processes and evolution. This is because MGEs can affect a microbe’s … cycles around them. By understanding more about the genomics of MGEs and their evolution at the cellular level, …
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Directed Evolution of Flavin-Dependent Halogenases for Site- and Atroposelective Halogenation of 3‑Aryl-4(3H)‑Quinazolinones via Kinetic or Dynamic Kinetic Resolution
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Building Sphagnum Genomic Resources
Science Program (CSP), researchers are developing a number of resources to build up Sphagnum as a plant model system … as “an unparalleled model system for ecological and evolutionary genomics .” Understanding the nature and genetic basis of …
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Learning to Look
… “Where’s Waldo?” readers need to look for a number of distinguishing features. Several characters may be … to conduct a similar type of search in microbial and metagenomic databases. In this case, the machine “learned” to … are important from the standpoint of phage-bacterial coevolution and are also useful tools in CRISPR-Cas …
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JGI Mural
The JGI mural on the 3rd floor of the Integrative Genomics Building whimsically references … to advancing the frontiers of environmental and energy genomics. Click on the images below to learn about the …
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The Expanding Universe of Methane Metabolisms in Archaea
… gas 20 times more potent than carbon dioxide. Billions of years ago, methane-producing archaea likely played a key … important to understand early life, but also to link the evolution of this metabolism to geochemical data, which in … enzymes.” Gribaldo will be speaking on “Exploration of Metagenomic Data to Understand the Diversity and Evolution of …
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Igor Grigoriev
… protists to plants. In 2009, he launched the JGI Fungal Genomics program which resulted in over 2500 fungal genomes … Ye et al (2022) The role of zinc in the adaptive evolution of polar phytoplankton.  Nature Ecol Evol . … … Fungal & Algal Science Program … Education … Selected Publications … Awards and Service …
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A Complex Confection Decoded: Sugarcane Reference Genome
… most harvested crop by tonnage, sugarcane accounts for 80% of global sugar production. A reference genome for the … the HudsonAlpha Institute for Biotechnology and the Arizona Genomics Institute. The work was partly enabled by the JGI’s … of the diversity present in R570 but shows the genomic effects of breeding practices that transformed …
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Evolution of a multi‐step phosphorelay signal transduction system in Ensifer: recruitment of the sigma factor RpoN and a novel enhancer‐binding protein triggers acid‐activated gene expression
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Enlarging Windows into Understanding Gene Functions
… in sequences affect traits. In a text file, the rows of letters A, T, C and G appearing over and over in a … in the genome by adding tagged transcription factors to a genomic DNA library. “It’s an innovative way to rapidly … where transcription factors have been repurposed during evolution to control new functions,” O’Malley said. …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… a new methodology, scientists are now getting more complete genomic results from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for understanding the … usually employ two different methods; shotgun metagenomic sequencing and single-cell sequencing. For years, …
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A Community Resource for Secondary Metabolite Researchers
… user engagement. The Science In addition to the core set of "primary metabolites"—chemical compounds shared by most … growth and reproduction—most organisms produce a set of "secondary metabolites," chemical compounds that often … more than 13 million BGCs in the catalog at the time of publication, it is the largest repository of BGC sequence …
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