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Extracting the Secrets of Secondary Metabolites
… combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those … paired CRISPR and CRAGE technologies. While CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is … and other industries — yet there’s still so much about them we don’t know.  Unlocking the power of secondary …
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iPHoP: A Matchmaker for Phages and their Hosts
…   To understand virus-host dynamics, computation helps fill in what cultivation can’t. The Science At first, viruses are merely toolkits. To do anything, they must find a host, and not just any host will do. It must be a … (https://ror.org/04xm1d337), a DOE Office of Science User Facility, is supported by the Office of Science of the …
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Taking Stock of the Known and Unknown Microbial Space
… (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Lawrence Berkeley National … assesses what fraction of the microbial diversity we know about, and proposes a path forward to curate and cultivate … bacterial diversity. The team conservatively estimated that about 42% of the bacterial diversity has no genomic …
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Mapping Heat Resistance in Yeasts
… species to grow better than its closest relative S. paradoxus at high temperatures (39°C/102°F). The Impact One of the … DOE Joint Genome Institute (JGI), a DOE Office of Science User Facility of Lawrence Berkeley National Laboratory, aim … improve functional annotation to harness the genomic data. Reported October 8, 2018, in Nature Genetics , a team led by …
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Gut Fungi: Unexpected Source of Novel Chemicals
… off early from aerobic fungi, which can breathe oxygen — just like we do. Oxygen is a rich source of energy, and because anaerobic fungi can’t harness it, scientists long held … Neocallimastix californiae , and Piromyces finnis . In work reported in 2017, the fungal genomes were sequenced by the …
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An Enzyme System to Help Catalyze Bioproduction of Plastic
… reductase system, researchers could open avenues for using bacteria to produce ethylene and more.  Microbes excel … miscellanea of their surroundings. Case in point: for us, the smell of the ocean simply signals we’re near the … contexts.  “That allows us now to really start thinking about the structure-function relationship. What could we do, …
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Supporting Global Research into Actinomycetes
… special groups of actinobacteria Streptomyces is more than just a funny word. The 500 species described within the group … new antiviral medicines and treatments for infectious disease. Streptomycetes are also abundant in soil and can … in the JGI Natural Prodcast podcast , where she talks about this community resource. ) “Most people study …
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Enlarging Windows into Understanding Gene Functions
… (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Lawrence Berkeley National … as tough as it has been 10 years ago,” he said. “We thought about reconstructing gene regulatory networks, understanding … team is comparing five fungal species to answer questions about how they break down plant materials, which could be …
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Supercharging SIP in the Fungal Hyphosphere
… have successfully automated aspects of a commonly-used process for studying microbial communities, with … The Impact Stable isotope probing is a long and laborious process — as well as a key way scientists study microorganisms. Because microorganisms live in complex communities, like within …
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From Competition to Cooperation
… walls, while brown rot cannot break down the lignin but use cellulose. Finally, there are soil saprotrophs, which degrade plant detritus. Despite the different modes of nutrition, many of these … in moving toward functional genomics studies to learn more about the inner workings of plant-host and …
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Soil virus offers insight into maintaining microorganisms
… Using the IMG/M data portal, researchers have identified a virus protein tied to carbon cycling.  The Science Through a … effort, researchers have identified a protein in soil viruses that may promote soil health. The work was enabled in … Research (BER) and is a contribution of the Scientific Focus Area “Phenotypic response of the soil microbiome to …
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Fungus Fuels Tree Growth
… a potential biofuel feedstock.     The Science The fungus  Mortierella elongata enjoys a dual lifestyle; it can … an endophyte, living between a plant’s root cells. The fungus is almost always found among and within poplar trees, and … were striking. Adding PM193 caused poplar cuttings to grow about 30 percent larger by dry weight than without PM193  . …
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