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… is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which … T ., Klenk H. P., Kyrpides N. C. 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life.” Nat …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… improving air quality and promoting a circular economy. Acetogenic  Clostridium is considered the most efficient … strain for the production of biofuels and bioproducts from low-cost gas feedstock. For more information about the …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types …

Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … develops data science tools for workflow management and novel automations for DNA design, assembly and analysis … platform enables users to validate hypotheses generated from mining genomic data by designing and assembling …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … in a microalgae. There were four genes there. Not like a bacterial gene cluster, but they were still clustered in the …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … of the opinion that on the geological timescale, that most bacterial natural product systems evolved, you know, a …

… lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …