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… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … Bill Fenical. And we connected to JGI through the Community Sequencing Program, and they worked with us to sequence two … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… really the same kind of thing. Before the age of genome sequencing, we had to basically break up the pieces of DNA … And you would scan those pieces by hybridization or maybe sequencing if you were rich enough. [CHUCKLES] And once you … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… processes, development of high performance plants and microbes, and understanding microbiome interactions. The  … insights into how small molecules function within plants, microbes, and ecosystems. Identifying and analyzing primary … range of biological and environmental samples — including microbes, fungi, plants and soils. Through a combination of …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve …

… started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology to help … because – mainly it’s due to the emerging technology on DNA sequencing and synthetic biology. But also the metagenomics … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the …

… For sequencing projects, once work is under way, raw sequence … More on Sequencing Projects …

… by generating data in three overarching categories: DNA Sequencing , DNA Synthesis and Metabolomics .  Many users …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in the group include the sequencing and comparative analysis of thousands of archaeal …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … The Fungal & Algal Program harnesses cutting-edge sequencing technologies and advanced genomic analysis to … and biogeochemistry. The program’s focus is on large-scale sequencing efforts that survey the vast phylogenetic and …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  DAN:  And … doing was pursuing with Jacques Ravel, at TIGR, metagenome sequencing, which was very early days for that technology. …