Search

… activity. So the chemistry and function really of those microbes that live there.  And in our work we’ve determined … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … really exciting work on figuring out how to get genomic sequencing data for the fungus garden because it’s more …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … is similar to primary metabolism. So if you were, you know, sequencing an organism for the first time, and you’ve never …

… really the same kind of thing. Before the age of genome sequencing, we had to basically break up the pieces of DNA … And you would scan those pieces by hybridization or maybe sequencing if you were rich enough. [CHUCKLES] And once you … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … Bill Fenical. And we connected to JGI through the Community Sequencing Program, and they worked with us to sequence two … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

For accepted proposals, sequencing, synthesis, metabolomics and analysis will be … with DOE mission-relevant projects that call for expansive sequencing, synthetic biology and metabolomics capabilities … Letters of Intent. Proposals may include synthetic biology, sequencing and metabolomics. Proposals may include synthetic …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve …

… started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology to help … because – mainly it’s due to the emerging technology on DNA sequencing and synthetic biology. But also the metagenomics … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… resources empower students through isolation and genome sequencing of new fungal species.  Students collect fungi, … into iNaturalist. Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 … laboratories with minimal overhead (cost of media, ITS sequencing and tissue preparation), allowing participation …

… community at large with access to high-throughput sequencing, synthesis, and metabolomics at the JGI for … based on their DOE relevance.  For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… manager may then schedule and allocate resources for DNA sequencing. … No. However, the JGI does maintain a list of … … Guidance on international shipments can be found in the Sequencing Sample Overview file in our HERE (TK) .  Note: … be accessed via the Genome Portal , at the following sites: Microbes: IMG (citation: https://doi.org/10.1093/nar/gkaa939 …