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DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … wise maybe, what genome mining is, then, is looking at DNA sequence and trying to find the things that you want to … worked is people who were trying to find gold would go out into the hills. And they knew from example that gold is a …

The JGI provides users access to cutting-edge cell sorting, DNA amplification, and sequence analysis to recover the … activity (BONCAT+FACS). To provide additional functional insights into microbial genomes, the JGI now uses laser …

…   The JGI provides integrated high-throughput sequencing, DNA design and synthesis, metabolomics and computational … sequencing scores of microbial species as well as several model organisms and contributing this information freely to … strains, or enzymes to convert plant biomass components into fuels, chemicals, and bioproducts, or to control …

I talked about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, … it will be really good to maybe start with how did you get into this field? How did you get into natural products? … I think this is really– I personally like this really as a model for a collaboration. You have your code as open source …

Kerrie Barry or Vivian Ng Prokaryotic projects: Tijana Glavina del Rio , Danielle Graham , or Miranda Harmon-Smith DNA Synthesis projects: Miranda Harmon-Smith Metabolomics … manager may then schedule and allocate resources for DNA sequencing. … No. However, the JGI does maintain a list …

… for every episode we put out. I actually put a lot of time into preparing those transcripts, so I hope somebody’s going … because – mainly it’s due to the emerging technology on DNA sequencing and synthetic biology. But also the … natural product – they also often surprise us by giving us insights, inspires us to discover the fundamentals and then …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental … phage function in this tripartite plant-bacterial-phage model system. We seek to expand beyond this model system by identifying phages and characterizing this …

The JGI has a strong interest in seeing that the data produced by the facility … below) for the generation of sequence or metabolomic data, DNA synthesized, and any other contributions, such as … well as in advanced assembly and engineering strategies for DNA synthesis applications. If JGI personnel contribute …

Developed in 2017, the PDT was established in part to help … method of converting abundant low-cost gas feedstock into valuable bioproducts, but many  Clostridium strains are … JGI Metabolomics Science Program Head Yasuo Yoshikuni, JGI DNA Synthesis Science Program Head Ian Blaby, JGI DNA …

… and you can still make more of it, then you start going into human trials or animal trials first, and going through … 80s and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – … to go ahead and, and synthesize those genes within a model organism like E.coli , and have it produce the …

I wanted to start, maybe just by asking you how did you get into the field of natural products?   NANCY: Yeah, that’s a … to begin with. So transformation, or manipulation of the DNA of genes and bacteria, occurred much faster earlier than … more interested just to see if we can use Aspergillus as a model for expressing hard to work with eukaryote [genes]. So …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … than it is now. Or a little more– yeah, put more rationale into drug discovery by knowing what these things actually do … to hear from you. We have projects in genome sequencing, DNA synthesis, transcriptomics, metabolomics, and natural …