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… Doering and Bryce Foster and too many others to name at JGI for the last two years or so. SMC is now released and ready … first exposure, my junior year as an undergrad. And to me, looking at the chemistry of the molecules and then looking … we can put together. What makes it a little bit different beyond that– and sorry, I’m just going to keep babbling …

… to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting some conversations … use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And they have all … tissues, different structures, different spores. I like looking at that I’m a very visual person. So, when we make …

… Dan Udwary: Hey everybody! Welcome back for Natural Prodcast episode 17. The guest we have this week … bioprospecting that is often done, where we’re really just looking at DNA sequences, and we don’t always know … is I really try to find experts that are able to take it beyond that initial screen because I am not an expert in …

… I wanted to tell you about in this introduction. First and foremost, our interview this week is with Professor Brian … evaluated. So we started to see this potential of looking for compounds based on these gene clusters. And that … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique opportunity for researchers to request the capabilities and expertise of … at least two of the facilities, and generate datasets beyond what each of these facilities could generate by …

… of single-cell genomes and directly link functional information with individual cells. Research Team    … activity levels.This functional assay lets us move beyond cataloging the genes of microorganisms and start … that allow us to select specific uncultivated microbes for sequencing based on their level of metabolic activity …

… staff in the Integrative Genomics Building in Berkeley, California.  Our location at the IGB fosters team science and … JGI is focused on supporting the DOE missions in energy and biotechnology through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, …

… and the bacteria and how the chemistry is going back and forth between them is part of what fascinates me about what … products chemists and biologists, natural products folks, looking at the tropics because of this immense amount of … working on but we’re not exactly working on that. So it is beyond the realm of- I wouldn’t even know how to start if I …

… so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. You know, we have this … products. And so we’ve got another slide here, and we’re looking at a hand drawing – drawn by Selman Waxman, who was … discovered. This is a time when all the big drug discovery companies were creating libraries of soil bacteria they kept …

… of the process needed to prepare and ship samples for sequencing by the JGI.  Additionally it includes … quantity and quality has been the rate-limiting step for many projects at the JGI. The quality of the starting … sequencing workflows and provide guidance as to how to perform sample QC prior to shipment: Importance of Sample QC …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … went to group meeting and came back and it was just so fun looking at this as someone who had a bit more of a chemistry … there to find natural products that may have been missed by companies like Pfizer or Wyeth or that because they probably …

… and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … things. I’m going into architecture and I did that. And looking at all those art history photos of the, you know, … it would, someday. And there are a number of industrial companies doing just that. So I think there’s some fantastic …