Search

… via the Integrated Microbial Genomes & Microbiomes (IMG/M) system. Research Team    … The Integrated Microbial Genomes … of the Integrated Microbial Genomes (IMG) data management system … As part of this project, pairwise average … made it possible to confidently assign species to nearly 326 genomes. Through the analysis of cliques, it has also …

NOTICE Information from this server resides on a computer system funded by the U.S. Department of Energy. Anyone using this system consents to monitoring of this use by system or … U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Accordingly, the U.S. Government retains a nonexclusive, …

… genomics data types as well as in advanced assembly and engineering strategies for DNA synthesis applications. If … of publications and allowing connections between all systems to maximize the impact of user research. The crucial … following the guidelines below.  … If you use data from 3 or fewer JGI proposals, include those DOIs in the auspice …

… wanted to be true to my roots, and always work with marine systems because that’s just where my innate curiosity and … are those genes induced. Well it turns out, you know, high CO2. Turns out you know, when nitrogen levels change in the … medicine” as a way of the future. We’re really good at engineering small molecules into microbes and making those …

… environments. … KBase is a critical partner in enabling systems biology analyses, such as metabolic modeling, that … from single genes and individual genomes to metagenomes to systems-level modeling and understanding. JGI and KBase are … National Energy Research Scientific Computing Center … DOE System Biology Knowledgebase … National Microbiome Data …

… that mimics chloroplast function within a cell-sized system. The Impact Photosynthesis harnesses carbon captured … an artificial photosynthesis pathway that would more efficiently remove carbon from the atmosphere than current … (ECR) enzyme variants. ECR enzymes are capable of fixing CO2 many times faster than RuBisCo, the most common CO-2 …

… that meant.  I was a chemistry major after being an optical engineering major after which was really laser physics, and … strain and there have been years and years and years about 35-ish years, I think, now, studying Vibrio fischeri and … to that and what you guys do when you’re exploring your systems. Because I think the JGI has a little bit of a …

… for a long time about the evolution and natural products systems. This conversation came about because he challenged … I think, not only us but many people– are typically very inefficient, not specific mechanical molecular motors or … about being able to do. FRANCISCO BARONA-GOMEZ: Yeah, truly engineering and going beyond what nature has evolved, which …

… there. This is Dan again, and you’re about to listen to the 3rd and final part of Natural Prodcast’s “Primer” episodes. … DAN: Well, it is and it isn’t. It depends on different systems of secondary metabolism and the things that are in … not actually on the structure of the protein that you’re engineering… Yeah, the complete system. So there’s more to …

… of these really interesting molecules, oftentimes much more efficiently than we can in the lab. And so that's how I got … can turn on the natural product, say clusters or expression systems so that-- BETSY PARKINSON: Exactly. DAN: --you get … thioesterases, we were actually able to find approximately 300 with NRPSs nearby. And of those once we did the …

ALISON: It sounds like it’s kind of like our endocrine system or hormones in a way too. Like in a maybe analogous … But… DAN: Yeah, there are a lot of ways to put together carbon molecules. Chemistry is pretty limitless. All right, … a conversation from the first episode . You can go to part 3 here . You can find the podcast on  Apple ,  Google ,  …