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… resources that support user analysis of biogeochemically-relevant pathways, enabling modeling of microbiomes based on functional traits. These advancements provide new insights into …

The Community Science Program (CSP) provides the scientific community at large with access … of disciplines. Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that …

… conference, which took place a few weeks ago, in January of 2020. So, you might hear us referencing a conference, and … with. So transformation, or manipulation of the DNA of genes and bacteria, occurred much faster earlier than they … (SIMB) Natural Products meeting in San Diego in January 2020. You can find the podcast on Apple , Google , Spotify , …

… and looking for secondary metabolites in the genome as relevant to the JGI mission? DAN UDWARY: Yeah, that’s a … in most fungi, biosynthetic gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, … Catalog of Earth’s Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) The GEM catalog …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … organisms? Can you manipulate them? Or can you move the genes and heterologously express them? Is there like a great host that you could use if you can’t knock genes out? AARON PURI: Yeah. It’s a great question. So that …

… mining-based approaches are that other than resistance genes, you have no way of knowing of whether or not a … is going to be active. And even if you do have resistance genes, it may not be better than something that already … more. You need other prioritization techniques, resistance genes or something. DAN UDWARY: Right. Right. Right. Right. …

… organisms actually have quite a few antibiotic-resistant genes in there. And so we’re trying to use those as … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … was the Salinispora genome project. And that was a JGI CSP project. They sequenced that genome for us at a time …

Catalog of Earth’s Microbiomes .  Nature Biotechnology . 2020 Nov 9. Vyshenska, Dariia et al. (2023)  A standardized … Catalog of Earth’s Microbiomes .  Nature Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6. Ladau, J. et al. …

… genome sequence and genomic toolkit for the perennial grass Miscanthus sinensis has been published. Analysis of … (perenniality). The Impact Among the long-term aims for bioenergy feedstock crops are increasing their yields and … and more complex patterns of inheritance. The additional genes provided by these chromosomes can contribute to novel …

Do you think that they always cluster or could the genes be separated on a genome?  Dan: Oh yeah. It’s biology … and a JGI project around ants and their fungus farms.  Relevant Links Some of the work we discussed about bobtail … on increasing computational skills among biologists JGI CSP Proposal: Metagenomic mining of natural product …

… on an accelerated timeline as compared with the standard CSP projects. In addition, they must utilize a broad range …

Natural Products conference, which took place last January 2020 in San Diego. San Diego, of course, is the “home turf” … genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …