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… the rest of the archaea and fungal genomes and then work on metagenomes. So yeah. So we’ve taken every public sequence … to us. It could be a metagenome. We’re going to run metagenomes. That’s going to take a while. [CHUCKLES] But … like massive brownouts in California when you’re doing the computational analysis of metagenomes. DAN UDWARY: Well, the …

… the enediyne we have isolated to date by the traditional methods. But more importantly, we hope through enediyne that … to translate the DNA into the small molecule – if these methods are very effective, that is, if the natural product … fungus, even more. And of the fungus, we have more than 2600 different species. But you have to take the historical …

… The User Support Analysis group provides computational analysis for new technology development and …

… antiSMASH has been sort of a good aggregator of different methods that people use when they’re doing homology … set of MAGs to date. Here, at JGI, we took more than 10,000 metagenomes, many of which were sequenced at JGI, and some … TAKEMURA: –just give me a few examples of where these metagenomes came from? DAN UDWARY: Oh, yeah. These things …

… plant and other efforts. The JGI works closely with DOE computational facilities (e.g., the National Energy Research …

… microbes , scientists usually employ two different methods; shotgun metagenomic sequencing and single-cell … amplification at a large scale. Summary The two most common methods for collecting genomes from microorganisms are …

… predicted functional and metabolic roles across global metagenomes (within IMG).  The Impact The initial analysis … protein-coding annotations in all IMG metagenomes. The work is of interest to the Department of … in microbiomes. The initial analysis used over 12,000 metagenomes from diverse environments and grouped those with …

… compounds. To support users, our efforts include developing computational tools for predicting biosynthetic gene … and determine their binding sites across multiple genomes. Computational prediction of heterologous expressability: We … host to express their BGC(s). This is based on extensive computational analyses of BGC size and complexity, BGC …

… Machine learning methods were applied on sequenced fungal genomes to classify …

… for you, we sequenced thousands for you or thousands metagenomes. And I think also the quality that we provide. … gets analyzed. And in a way that helps the PI, I think. For metagenomes and microbial genomes, in part because of the … of those individuals. Also, if you need a “Materials and Methods” section, we can provide that information as well. …

… them. And so, I spent a number of years trying various methods, back in the old days, to figure out how they’re …