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… has historically been limited due to the lack of robust tools available for carrying CRISPR into microorganisms. … of interest. Using CRAGE to domesticate target microbes, users of the U.S. Department of Energy (DOE) Joint Genome … monitor loss- and gain-of-function. The study’s analytical data shows peaks and valleys in secondary metabolites as …

… interests lie in use and development of bioinformatics tools for elucidation of biosynthetic gene clusters in …

… reactions. For this article alone, more than 600 genomes (dubbed “GEBA-Actino”) were sequenced from DSMZ type-strain deposits. All of these genome sequences and the tools to compare them are available on the JGI’s Integrated … gene loss shape the BGC repertoire in most genomes. The BGC data will also soon be contained within the JGI’s Secondary …

Biology Knowledgebase (KBase), the National Microbiome Data Collaborative (NMDC), and Berkeley Lab Biosciences Area … Mission  As a U.S. Department of Energy Office of Science user facility, we provide advanced genomic capabilities, … Biosurveillance and Biopreparedness. With this plan as our guide, we’ll continue to enable basic science in support of …

… remembering to document his code. At JGI, he develops tools for viral discovery and analysis, with a particular …

… and renewable chemicals, developing genome engineering tools for non-model organisms, modulating microbe-microbe …