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… so they’re secondary metabolite peptides. And there are two ways that nature does this. The more well-known … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… on the way – I’m going to try to keep them coming out every two weeks for a while – so I hope you’ll be listening. But … already had a fermentation process with already engineered strains, but this was to further build on those to try and … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

Below is a brief description of the process needed to prepare and ship samples for sequencing by the JGI.  Additionally it includes … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

JGI Mission As a U.S. Department of Energy Office of Science user facility supported by the … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … and fungal metabolism necessary to design communities, new strains, or enzymes to convert plant biomass components into …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … is what. This is not new. It actually was first proposed by two authors called Firn and Jones. I’m sure that people … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of … to completion of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is …

… intriguing. The squid – the Hawaiian bobtail squid has two organs that solely house– whose sole function is to … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … automations for DNA design, assembly and analysis Overview of synthesis products The JGI DNA Synthesis platform enables …

The mission of the Joint Genome Institute is to serve the scientific … discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  The DOE Systems … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … resources, but they don’t necessarily have the support network, the equipment, the facilities to really apply the … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … lots of stuff. On average, we had something– I think we had two biosynthetic clusters per MAG, which is pretty good …