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… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … disparate environments. There’s some marine. There’s some soil samples. There’s human gut samples. There’s lots and …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … for antibiotics and the microbes that make them is in the soil. There’s … uh… there’s an issue there though, in that …

… sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs … in length, cloned into vector of choice Glycerol stock of sequence verified clone 170/NA DNA Synthesis Constructs …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … is a chemical compound called geosmin that’s produced by soil bacteria that live all over the place. So that smell of … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some …

… organs that solely house– whose sole function is to house bacterial associates. And so the one that the Hawaiian … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … products because they’re easy to find. They grow in the soil. These are the same guys that produce geosmin. And so …

… and culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… advantages for farmers concerned with improving sustainable soil management practices. … In June 2020, the Department of …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … this collection in total contains approximately 100,000 bacterial strains, and a hundred thousand fungal strains. …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … I’ve seen you give a few talks on that. Can you tell us why cone snails are so cool? ERIC:  So cone snails are … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … section. We want to be sure that the PIs can articulate why their work falls within one of these DOE mission areas. …