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… and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … implementation of prokaryotic systematics across cultured microbes and recovered population genomes using Average …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … that I never anticipated starting– that’s not why I came to the University of Utah– is looking at the … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … there you go. [laughs] ALISON TAKEMURA: All the more reason why it could have been inspired by Super Smash Brothers. DAN …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … where smaller proposals may be a fit. Still not 20 many microbes. We still we work in plates, right? We’re a high … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And they have all … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… LanzaTech ($LNZA) is a public company that uses engineered microbes to ferment waste industrial gases into valuable … our User Program’s Community Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium … Project to study how methanotrophs — a class of microbes closely related to the company’s Pink Pigmented …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… activity. So the chemistry and function really of those microbes that live there.  And in our work we’ve determined … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … or you know, you’ve run into challenges that demonstrate why this is so important. BEN:  Yeah. So I wouldn’t call it …