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… and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, archaea, they all have … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, microbial communities, … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … of our Community Science Program, characterize organisms (plants and microbes) relevant to the DOE science mission …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key to organisms' interactions …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … called “disease suppression”, where the microbiome of a plant, so the bacteria living on and inside the roots are …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … transcriptomics, metabolomics, and natural products in plants, fungi, and microorganisms. If you want to …

… from the University of Michigan. Dr. Narayan is currently associated with the chemistry department as well as the life … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… ag[riculture] and I really liked – I became interested in plant disease in part because of what happened in my Peace … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… chemicals that are coming out of organisms, whether it be a plant or from the bottom of the ocean, from a sponge, or a … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… bacteria, archaea, and micro-eukaryoes, along with their associated viruses and mobile genetic elements. Beyond … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes … genome and metagenome sequencing projects, and their associated metadata, around the world. …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … product chemistry? BEN:  Yeah. So, I was trained as a plant natural product chemist. When I first started in …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger … transcriptomics, metabolomics, and natural products in plants, fungi, and microorganisms. If you want to …

… to do an independent study on ethnobotany of some of the plants that people were using for medicines in this very … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …