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… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … as our gut? And can you be able to re engineer the gut microbiota to deliver medicines to humans? That’s something …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … mSystems. 5 (3) Schulz et al. (2018) Hidden diversity of soil giant viruses. Nature Communications. 9 (1), 1-9 Schulz …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … for antibiotics and the microbes that make them is in the soil. There’s … uh… there’s an issue there though, in that …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … disparate environments. There’s some marine. There’s some soil samples. There’s human gut samples. There’s lots and …

… … Adaptive strategies in a cosmopolitan and abundant soil bacterium: genetic microdiversity or core metabolic flexibility? … Microbial contributions to soil carbon storage during simulated range shifts of … advanced bioenergy crops … Characterization of simplified soil communities with high and low carbon use efficiency …

DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … products because they’re easy to find. They grow in the soil. These are the same guys that produce geosmin. And so …

… … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … off through these areas. And you can do– with a teaspoon of soil from outside, you maybe have to do a 10,000-fold …