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… know through professional circles in some way or another. But today, we have someone who, weirdly, I haven’t, I think, … heard of anthropology. This is– I grew up in a very rural, small town. We didn’t have AP or IB courses or any of these … bugs out of that or whatever. And so I was intrigued by the small section in the book about the conflicts between ideas …

… and, so, I don’t really have any trouble understanding him, but I know from the download stats that we actually have a … toxic molecules, and that human beings know, today, for small molecules. So they’re in the picomolar range. ALISON: … it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that immediately inspired people …

… that would be Katherine. Dan Udwary: Right. Kate Duncan: But most people that know me call me Kate. Dan Udwary: … around countries. And I was actually in Croatia on a small island off the coast in the Adriatic Sea, and I … And you kind of build your knowledge from the things, the small pieces that you know, to expand that out. And then you …

… isn’t as good as what you’ll hear in other episodes, but it’s not terrible. I was able to clean it up quite a … cases. MARC: Yeah, and in some cases of really extremely small genomes, like symbionts that can’t live without their … so we were at Warp Drive Bio. This was in Cambridge, Mass. Small… I guess we’d call it a small startup – while we were …

… I’m really looking forward to getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the … any water that washed down off the hills might carry small pieces of gold along with them and end up in the beds … then I would take a couple of the domains, which are small pieces of the sequence of a polyketide synthase. Each …

… we can identify most secondary metabolism pathways now, but there’s still almost certainly unusual things that we … yeah, so these guys, it turns out, produce lots of really small molecules that they use to communicate – lots of … spots around that?  ALISON: Oh, they’re so much smaller. Streptococcus is losing! DAN: Yeah, so that’s …

… trying really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m really happy today to be handing … So cis versus trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did … asking, could we try and do this with something that's smaller than the enzyme - some bio-organic type catalyst? …

… Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned … Synthesis Constructs 5-10kb in size Single gene or multiple small genes assembled totaling 5-10kb in length, cloned into … Synthesis Complex libraries Multiple variants of sgRNA or a small coding gene assembled together in various combinations …