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… on DNA sequencing and synthetic biology. But also the metagenomics and gut microbiome, as I think that it’s like a … is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: … DAN: Yeah, I don’t think your lab is gonna tackle that single handedly, right? So, yeah, getting the community …

… and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … communities and ecosystem function.  The Environmental Genomics group also hosts the Viral Genomics group . …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … and ecosystems at the molecular level. Integrating genomics with metabolomics fuels the discovery  of novel … processes, development of high performance plants and microbes, and understanding microbiome interactions. The  …

… come, though, too when you start talking about going after single gene clusters. BRIAN BACHMANN: That’s right. JACKIE … mammalian systems. But it allows us to assay on a single cell level against cell lines and against primary cells … mechanistic enzymology to natural product biosynthesis to genomics to directed evolution– but it’s just the– it really …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential … types) (Nature Communications 2017, Science 2018, Molecular Cell 2019) and massive reconstruction of genomes from … Bowers RM, et al. (2017) Minimum information about a single amplified genome (MISAG) and a metagenome-assembled …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, that maybe … great conversations that we’ve already recorded with some excellent scientists, and that’s probably how we’ll continue …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … streams. This will all become clearer as we get into the genomics. So– ALISON TAKEMURA: I’m just enjoying the ride … IMG data portal , which is a larger portal for microbial genomics. IMG stands for Integrated Microbial Genomics. It’s …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based …

Christa Pennacchio   … You can visit the Products & Offerings section of our website for more details, including … required documentation here .  … You can request a JGI Single Sign On account at https://signon.jgi.doe.gov . This … ) Metagenomes and Single Cells: IMG/M   (citation: …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … I think the important thing to remember is that, thanks to genomics, we now know that it is very hard to find stuff … for example, in terms of the stereochemistry, such that single changes can lead to a particular high activity …

… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … and finished genome derived from an uncultured bacterial single cell – a symbiont of the green sharpshooter. In 2012, … in carbon fixation in the dark ocean. Combining single cell genomics and synthetic biology, a team studying microbial …

The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … into bioenergy and bioproducts. The program’s fungal genomics research explores new metabolic processes and … seeks to expand our understanding of algal biology using genomics and multi-omics by working with research labs and …