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… grade science fair project where I first looked into a microscope and just fell in love with this invisible world … the fact that many of our modern medicines are derived from nature, and in many cases from plants. And so I think of … people aspects of things, because a lot of what we do at JGI in terms of the sequencing that we do is very …

… state of things, and what we’re hoping to accomplish at JGI in this area. If this series of podcast episodes has … recommend David Hopwood’s book called  “Streptomyces in Nature and Medicine.” It’s obviously focused more on the … is doing a chemical reaction. And then the final product is released. And you’ve got this molecule called erythromycin, …

… know a lot about them by their mate, what their role in nature, how have they been selected for or how do they … all these very, very related genomes, right – on their 16S level, they’re almost identical! But seeing all these … was fascinating, I think. DAN UDWARY: Yeah, and that was a JGI Community Sequencing Project. You’re right, yeah. NADINE …

But um, yeah, so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. … have that goal. That’s not as much our goal here at the JGI – we are not a medicinally focused organization. And so, … a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can find links to transcripts, …

… secondary metabolite peptides. And there are two ways that nature does this. The more well-known secondary metabolism … can use peptides for! That’s what his collaboration with JGI is all about, and we talk about it a bit here. I have … a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can find links to transcripts, …

… the US Department of Energy (DOE) Joint Genome Institute (JGI) commit to Lawrence Berkeley National Lab’s (Berkeley Lab’s) core values , which guide the …

… and head of the Secondary Metabolites Science Program at JGI, and also my boss, Nigel Mouncey. I got him on to talk … mention here that for this interview Alison was not available, but no worries, she’ll back next time! We’ve already … in-person part here at the integrative genomics building, Berkeley Lab, our home.  DAN: Oh, I haven’t heard anything …

… describe. [ Go here to learn more about Tiny Earth and the JGI’s role in the project by watching Amanda Hurley’s … we have no idea what natural products are doing in nature. And it’s a really difficult thing to unpack … a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can find links to transcripts, …

… think his energy is infectious. DAN: I’ll say up front that JGI recently started collaborating with Ben and his group to … fundamentals. What is beautiful for natural products is nature! Nature does this sort of – if you think of nature as … we have here – all of them were collected before 2016, before that true enforcement of the Nagoya protocol. And …

… of the first Streptomyces genomes that had just not  been released yet. And there was also some transcriptome data. … and domains, to identify enzyme coding genes that are signatures for the presence of a specific type of biosynthetic … of question have you applied them? Dan Udwary: Well, at JGI we have the Atlas of Biosynthetic Clusters . And this is …

… niche in chemical enzymology. So, we talked about her JGI DNA synthesis project to explore the chemical … candy corn, which is perfect timing for an October podcast release. I hope that doesn’t get me canceled.The monthly … also twofold but for different reasons to learn about how nature builds molecules because nature does this with such …

… understand the chemical diversity and chemical utility that nature has to offer us. I found this conversation really … let me know! I’m dying to hear from you. Toss an email to  jgi[email protected] , or leave us a review on Apple Podcasts … a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can find links to transcripts, …