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… in firmly in the chemistry bucket. [LAUGHS] I don’t know that that’s ever necessarily like a good description of … are those– they make chemistry! And so they – secondary metabolites, specialized metabolites, however we want to … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much …

… must be complemented with single-cell resolution assays that can be targeted towards specific phages and/or hosts. To that end, the JGI Viral Genomics group is exploring … of viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions. …

… Alanjary and Tilmann Weber to be a really valuable piece that shaped my thoughts about the history of genome mining … ZIEMERT: Big picture, I want to understand how secondary metabolites evolve– who makes them, how do they spread, why … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… goodness. I mean, if you were to find my scientific papers, that would be Katherine. Dan Udwary: Right. Kate Duncan: But … can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked science in … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … Program is focused on understanding the critical roles of metabolites in living systems, particularly as they relate … ecosystems. Identifying and analyzing primary and secondary metabolites helps uncover their roles in processes such as …

… for you. A lot of this is based on a really great paper that came out in 2020 where this is all explained in detail, … work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … and specialized metabolism, and natural products, or metabolites, were basically interchangeable terms in terms …

… this time. Let’s jump right in. — DAN: So secondary metabolites. I kind of inferred through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … pathways. Not every organism, at least, has something that’s maybe obvious or notable. We are still in – not an …

… Plants are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all contribute to a dynamic ecosystem. We are … fitness and health. This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can …

… the program investigates the biological mechanisms that enable fungi and algae to play a vital role in carbon cycling, biodegradation and biogeochemistry. This … with their ability to capture carbon and produce valuable metabolites. The program seeks to expand our understanding …

… proposals within the focused topic areas that can be completed on an accelerated timeline as compared … but proof of concept for the demonstration of a technology that would be applicable to DOE mission is appropriate. For … provides customized analysis, the JGI also participates in publication of results. …

… Management Office carries out a number of activities to facilitate world-class science. DOE JGI Project Managers … at https://signon.jgi.doe.gov ). Once users are notified that their proposal has been accepted, the PMO will assist … access your data, share with collaborators, and coordinate publication with JGI scientists. Synthetic DNA constructs …