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… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, … options. Note: In 2021, we conducted an extensive internal product audit to analyze the scientific value, demand, … DNA Synthesis Complex libraries Multiple variants of sgRNA or a small coding gene assembled together in various …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … produce secondary metabolites. Do you recognize this? DNA 🡺 RNA 🡺 Protein ALISON: This is central dogma. DNA to RNA to … smaller proteins all strung together. And this thing, the biosynthesis that happens here is really, really interesting …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … National Prodcast. This continues our little section on international genome miners, and today we have Francisco … and Jones. I’m sure that people excited in natural product biosynthesis overall have had read some of their papers and …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … Plant microbiomes hold the amazing ability to influence plant development, fitness and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a …

… is alive and well and doing very well. She’s a real journalist now. Just not working with me. AARON PURI: No, it’s … And that’s something that we are trying to do in our independent lab now is use these as a resource for natural … the cell, right? AARON PURI: Yeah. So we can dive into the biosynthesis of these as much as you want but they– so …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their associated … and viral activity, transcription regulation, and noncoding RNAs in microbiomes. The insights from this work have the …

… of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a pioneer … into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … But ultimately, they bought on. So now we have The Journal of Chemical Ecology that has a marine component. And …

… . And then coming up after that, we’ll have a lineup of international scientists who also do genome mining. We’ve got a … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … biosynthetic gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, those are clustered …

… Research in the Eloe-Fadrosh group focuses on using genome-resolved metagenomic approaches to identify and characterize genomic information from uncultivated microbes and viruses. We … focuses on the assembly of metagenomic sequence data into microbial genomes, which is of fundamental value to …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics … Exploring the fascinating world of giant viruses, which challenge our … Understanding the complex relationships between microbes and …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … drug discovery has been a major driver for natural product biosynthesis. And probably a lot of the people and the …