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… to tap into the largely unexplored biochemical diversity within secondary metabolites, expanding their potential … to organisms' interactions with their environments and with each other, from defending against predators to aiding in … systems to express BGCs that alleviate the constraints of cells and allow for substrates to be directed towards …

… 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … 2018, Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other … (2021) CheckV assesses the quality and completeness of metagenome-assembled viral genomes. Nature Biotechnol . …

… UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … That could be an origin story. DAN UDWARY: That’s really reaching. No, antiSMASH is the Antibiotics and Secondary …

… Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … that had the protein domain. And then for every clade within that phylogeny it made its own Soc? Pfam model, so … a gene cluster into BiG-SLiCE, BiG-SLiCE identifies for each gene that belongs to an important enzyme family to …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … So you are at the Scripps Research Institute. We’ve known each other for a while, you are definitely an expert in … is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: …

… Menaka Wilhelm, who is the host of JGI’s other podcast, Genome Insider . If you’re a Genome Insider listener, then … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we … also on the website, we have a lot of good information on each call, what are the deadlines for our large call. We …

… And then what actually brought me to natural products was reaching back into that love of the intersection of chemistry … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that … really, really important part of their ecology, are these cells communicating with one another. What can you tell us …

… profiling transcription factor binding sites across entire genomes. This technology has been further scaled to a … DNA amplification, and sequence analysis to recover the genomes of uncultivated microbes. We also apply labeling …

… off today with my interview with the Director of the Joint Genome Institute and head of the Secondary Metabolites … bringing these two businesses together. And so I’d reached this time when I thought, well, it’s probably time to … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… applications will focus on high-risk/high-payoff proposals within the focused topic areas that can be completed on an … two of the facilities, and generate datasets beyond what each of these facilities could generate by itself.   … provides customized analysis, the JGI also participates in publication of results. …

… to support the global research community in studies of complex biological and environmental systems. We optimize … predict, and design biological functions that can address complex challenges in resource resilience and economic … information into actionable insights and solutions. Genome-enabled biology provides solutions to strengthen …