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… for Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products … question would be much easier to answer if we had a ready mechanism for describing the chemical landscape of any … in lots of areas, we would like to do a better job of understanding gas phase reaction mechanisms. We would like …

And those have been looked at extensively. One of them is a drug that’s used to treat pain. It’s one of the only new, … And it’s structurally really varied. And so we thought by understanding that we could learn how to make peptides, … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

… has always been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We … producing molecules that are helpful to the plants. And so, understanding those broader environmental and ecological … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, …

… track in natural products, and especially if you’re in the drug discovery angle, is to look in industry. But you’re a … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever … that system is just not possible from– completely understanding the system is not possible from the tools that …

… of advanced biofuels that can be blended with existing transportation fuels. Researchers also study ways to develop …

… of course, we can use that knowledge to actually use it in drug discovery, right? I mean, at the end, we somehow have … actually can learn just by really digging into the data and understanding what’s going on there. And now, that’s all I … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… sustainability, and many other applications. By understanding how microbes contribute to ecosystem … the Program helps drive innovations that could advance our understanding of Earth’s ecosystems. … The Metagenome … One of the key goals of the Program is to develop a deeper understanding of microbial community assembly and microbial …

… the viral genomics group aims at improving our collective understanding of ecological and evolutionary parameters … uncultivated viral diversity, characterization of molecular mechanisms involved in virus:host interaction and host cell … abundant ocean viruses.  Nature . 537:689-93. … Selected Publications … For further information contact the Group …

… work I really became more and more interested in cancer drug discovery and pharmacology but I didn’t know how to get … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … those numbers are still actually pretty high in terms of understanding from just sequence gazing alone what those …

… for the project. DAN: Do you see broader applications for understanding these systems? AARON PURI: Yeah. Are you … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum … lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. …

… by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of … of microbial single-cell sequencing. Nat Methods 14(11): 1045-1054 (2017). Schulz F., Yutin N., Ivanova N. N., … … Research Interests … Former Lab Members … Selected Publications … For further details, please reach out to the …

… metabolism, has been … not dominated by, but driven by drug discovery. We know that many natural product molecules … caffeine, that do things for us that are positive. And so drug discovery has been a major driver for natural product … of secondary metabolism in the environment, and, sort of, understanding – like we’ve talked about – how bacteria or …