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… over our interview with Dr Elizabeth (or Betsy) Parkinson from Purdue University. She’s in the Department of Chemistry … its effects on regulation of natural product biosynthetic pathways, which led her to a successfully funded JGI CSP … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that …

… identify and interpret biosynthetic, secondary metabolism pathways. And today, we get to present our conversation with … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … relates to a whole different field like computational drug discovery field, which has been quite distinct from the …

… enjoyed what he was doing so I wanted to be part of that discovery, and that magic that he was showing, and in his … genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of a trend now. But at the …

… breaking our methods was these damn secondary metabolite pathways. So that’s kind of how I fell down the rabbit hole. … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … and now at University of Wisconsin and the Institute for Discovery here, are … surrounding Tiny Earth is to create a …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about … the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience …

… the only way a primary metabolite or a primary metabolic pathway is good for anything, it is if the final product is … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

They all have very developed secondary metabolism pathways. Not every organism, at least, has something that’s … that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … metabolism, has been … not dominated by, but driven by drug discovery. We know that many natural product molecules are …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … phenotypic differences in plants and will accelerate gene discovery. BrachyPan on Phytozome (see Brachypodium … the ability to discover syntenic orthologs, generate publication quality graphics and explore pangenome views of …

… with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …

Natural Prodcast is a “fireside chat”-style podcast about natural products and the science and scientists of secondary … to the chemicals that make species unique and different from one another. They are incredibly important to medicine, …

… the modern, post-golden age history of natural products discovery, and we’ll talk a lot about the current state of … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … you’re going to find another 20 or 30 secondary metabolism pathways that you didn’t even know existed. And so, that …

Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … ALISON: Okay. We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a …