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… improves understanding of the role small molecules play in diverse biological systems, sheds light on nutrient cycling, … of new molecules and pathways. The JGI Metabolomics Platform delivers rich metabolite profiles from diverse … they grow, as well as different types of environments (e.g. soil, lake).  A wide range of metabolites are identified …

… in Nature and Medicine.” It’s obviously focused more on the bacterial side of the field, and it’s a little hard to find … a new culture of a new bacteria that you pulled from the soil, maybe it’s, you know, we talked about sponges, go pull … lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … could imagine if you have two colonies of bacteria in the soil or something and they’re competing with each other, if … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … beautiful. Sorry about that! They’re actually beautiful and diverse organisms. And they also have a rich chemistry. And … really need to know how they’re made. You need to bring the genes into the lab, and you need to manipulate them in the …

… an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … are many others, including Streptomycetes, which are common soil bacteria. DAN UDWARY: Yeah, we talk about them a lot … in drug discovery, and exploring marine bacteria for novel chemistry. Related links: Bill’s early thoughts on …

… and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. … disparate environments. There’s some marine. There’s some soil samples. There’s human gut samples. There’s lots and …

… in the marine ecosystems and marine actinomycetes and cyanobacteria. And we thought we could also– let’s see what caves … off through these areas. And you can do– with a teaspoon of soil from outside, you maybe have to do a 10,000-fold … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into … products because they’re easy to find. They grow in the soil. These are the same guys that produce geosmin. And so …

… by exploring plants’ role in capturing carbon, detoxifying soils, interacting with other organisms, and adapting to environmental changes. The program lays the groundwork for sustainable solutions to current problems facing … species and plant-microbe interactions, advancing efforts to create renewable energy sources and bolster …

… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … currently exist. We looked at chemistry, so it’s really novel. And they’re just really exciting. And it really kind … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …