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… interactions with their environments and with each other, from defending against predators to aiding in symbiotic … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary … factors and determine their binding sites across multiple genomes. Computational prediction of heterologous …

And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … garden ant as well as the American honeybee. And so I have multiple opinions which I’m never short of but. In terms of … Do you think that they always cluster or could the genes be separated on a genome?  Dan: Oh yeah. It’s biology …

… the product and deliverables as well as target cycle times from sample receipt to completion of standard analysis.  Raw … DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned into …

Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … really seeing that. And I’m always just looking from the genes and pathways and what’s happening there. And he really … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … in most fungi, biosynthetic gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, … amino acid out of solution and stick another amino acid or multiple other amino acids onto it to create a small …

… is a bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, … It sounds like it’s kind of like our endocrine system or hormones in a way too. Like in a maybe analogous way. We … It’s an evolution of primary metabolism. So a lot of the genes and the DNA that’s used for secondary metabolism, they …

… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … organisms actually have quite a few antibiotic-resistant genes in there. And so we’re trying to use those as … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

DAN: Welcome back to Natural Prodcast! This is episode 4! From here on out, for a while, we’re going to be presenting … my Peace Corps volunteer stint, and that it was in all the maize. So the main food that you ate was called Papa, which … with. So transformation, or manipulation of the DNA of genes and bacteria, occurred much faster earlier than they …

… buck. The research team reports that transferring just four genes encoding these enzymes to another plant, such as  … terpene synthases and cytochrome P450s — that catalyze multiple products, resulting in many antibiotics. To uncover … ability make zealexins, and harnessed gene expression data from these lines to identify genes associated with zealexin …

… in the project by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] … breaking our methods was these damn secondary metabolite pathways. So that’s kind of how I fell down the rabbit hole. … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their …

… to more easily integrate the expertise and capabilities of multiple Department of Energy Office of Science National … provides customized analysis, the JGI also participates in publication of results. … All proposals undergo technical … The ranked proposal list, along with a recommendation from management at JGI and the other participating …

… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … team who have been really looking at ways to express genes in organisms that haven’t been used for really any … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …