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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … is that you could, therefore, expect a lot of chemical diversity. So many compounds will fulfill the same function. … the regulation off, rather than negatively get rid of the genes from their genome. FRANCISCO BARONA-GOMEZ: Exactly …

… Biology is currently experiencing a revolution brought on by rapid developments in … and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … advances in management, processing and visualization of “big data,” and artificial Intelligent/machine learning …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … associated with microeukaryotes, enhances our understanding of terrestrial biogeochemical cycling and inter-organismal …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … Yeah, bacteria sound like a good place, to me, to look for diversity because there are so many bacteria, because it is …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … see. So it doesn’t seem to be a correlation between biodiversity in taxa and biodiversity in secondary metabolites. …

… Plants are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified …

… was less nutrients but enough that you had a lot of biodiversity. So we choose environments that are close enough … by culturing them. DAN UDWARY: OK, what’s the taxonomic distribution? Is it significantly different than what you … if you want– if you really want to, you can do heterologous expression. You can do homologous expression techniques and …

… to more easily integrate the expertise and capabilities of multiple Department of Energy Office of Science National … aims to encourage innovative research exploiting a diversity of capabilities. Previously, researchers had to … provides customized analysis, the JGI also participates in publication of results. …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … you to get a bird’s-eye perspective on the biosynthetic diversity element of these genomes. And you see how they’re– …

… Undergraduate Research Experience (CURE) that consists of coordinated hands-on experiments across fungal biology teaching … species.  Students collect fungi, sterilize tissue, isolate genes and more. The metadata then goes into iNaturalist. … Beyond providing a scalable solution for production of high-quality fungal reference genomes, this program is an …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is … Phylogenetic diversity estimates show that the gap between cultivated and … gap is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… projects that address biological functions for biomanufacturing, critical minerals and materials, inter-organismal … and predictive biology, modeling and biodesign — questions of relevance to DOE’s Biological and Environmental Research … emphasis that are listed in the call and leverage the diversity of JGI technical and analytical capabilities. All …