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… cluster with me because it turns out that oftentimes in bacterial genomes if you have a quorum sensing system or the … that shows potentially it’s regulated by one of these small molecules, how would you go about finding what that … what signal is being made. And so we picked a bunch of very diverse ones to try to learn as much about it as possible …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding … metabolomics with genomic data to gain insights into how small molecules function within plants, microbes, and …

… Research in the Eloe-Fadrosh group focuses on using genome-resolved metagenomic approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational … focuses on the assembly of metagenomic sequence data into microbial genomes, which is of fundamental value to …

… BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … to the end. It’s not only the final product that is highly diverse, but also many of the intermediaries. And, in a way, … FRANCISCO BARONA-GOMEZ: Exactly. And I have just written a small piece where we discuss the future of merging …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … and that’s exactly what that does. But when you get more diverse, which, almost certainly, there’s a lot more stuff … chemistry but I think that’s not necessarily – There are small molecules that host make as well. And so hosts and …

… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that … genome annotation, improves understanding of the role small molecules play in diverse biological systems, sheds light on nutrient cycling, … Find more details on the instrumentation we use and our …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … chains of amino acids. “Peptide” is just another word for a small protein. And it turns out that a lot of natural … beautiful. Sorry about that! They’re actually beautiful and diverse organisms. And they also have a rich chemistry. And …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, Biodesign and pathway … Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned … microbial aggregate, or a specific subset of free-living cells. Extracted DNA may be amplified using whole-genome …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … yeah, so these guys, it turns out, produce lots of really small molecules that they use to communicate – lots of … like, you know, like an organism. They have specialized cells and the ecology there is really fascinating, probably …

… that need to defend each other or subdue one another with small molecules. DAN UDWARY: Antibiotics, yeah, to fight … But we’ve also done things where we’ve grown organisms in ultra minimal media. So you could take International … a single cell level against cell lines and against primary cells isolated from patients up to 12 markers at a time. And …

… and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … any water that washed down off the hills might carry small pieces of gold along with them and end up in the beds … of Earth’s Microbiomes. And what this is, is a data set of bacterial and archaeal genomes that were created – these are …