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… a DNA synthesis production group and a synthetic biology applications group. The DNA synthesis and assembly group: … as user facility that aims to provide access to state-of-the-art DNA synthesis and assembly technologies to the … We focus our efforts on integrating database mining and sequence design with scaling the production of large, …

… (Trillions) Operating Hours Goal Actual Total* Actual % of Goal Goal (hours)** Actual Total Actual % Goal FY 2025 … PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY 2024 DOE … = 91 days; Actual Operation = 24 days due to significant sequencer downtime related to the shelter-in-place. ††† …

… and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … discovery of new genes with important biotechnological applications (e.g., new CRISPR-Cas variants and new … Science 344(6186):909-13 … Research Efforts … Selected Publications … For further details, please reach out to the …

The Sequencing Technologies Group applies cutting edge molecular capabilities and state-of-the-art next-generation sequencing to enable biological … testing various platforms to see what works best for applications. The team works hand in hand with the Project …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … technology, but interesting biology and a potential application of translation in medicine. So it’s a really … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … responses. The program employs advanced mass spectrometry-based methods to analyze metabolites from a wide range of … in DOM cycling. ENVnet can be used in your custom Python applications but highly recommend using the workflow in  …

… … DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … scale a little bit for the project. DAN: Do you see broader applications for understanding these systems? AARON PURI: … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … helps translate their genomic potential into practical applications, including sustainable biofuels, biomaterials, … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

… … DAN UDWARY: Hey everyone and welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … them. And I would say that if you looked at the grant applications for the last 40 years for studying biosynthetic …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research proposal.  Successful applications will focus on high-risk/high-payoff proposals … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … within secondary metabolites, expanding their potential applications in the bioeconomy including biofuels, … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

Below is a brief description of the process needed to prepare and ship samples for … requirements for samples submitted to the DOE JGI. Plate-based Preparation Guidelines DNA Preparation Guidelines RNA … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …