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… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … do engineering to improve the physical properties of a protein and make it easier to work with. But sometimes, what … with the co-factor is bound throughout the catalytic cycle. So that co-factor stays in the active site. And then …

… The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique opportunity for researchers to request the capabilities and expertise of … or be otherwise mission-aligned, but proof of concept for the demonstration of a technology that would be …

… genomic science projects that address biological functions for biomanufacturing, critical minerals and materials, … inter-organismal interactions, and predictive biology, modeling and biodesign — questions of relevance to DOE’s … All proposals will be externally peer-reviewed for scientific merit, DOE mission relevance, proposed data …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … they can be things like biofilm formation. They can also be production, as we were mentioning before, of more complex … more structural diversity — so that one uses acyl carrier proteins as co-substrate. So the other ones they use CoA …

… not good at that, you guys. I’m trying really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m … bind similar ligands. And so one of-- DAN: OK. The similar proteins are going to bind similar molecules. Yeah, OK. … when I started doing a lot of this natural product production within bacteria, they're great at it, but it …

… I think it must’ve been about 2001, maybe, and so it was before smartphones and before laptops and everything. And I … as well. A lot of them have looked at applications like biofuels. Dan Udwary: Sure. Kate Duncan: But from a natural … from sediment cores in Antarctica that have– some of being carbon-dated to kind of 15,000, 150,000 years ago. So this …

… fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy and nutrient … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome interactions. The  insights derived are crucial for advancing the bioeconomy, environmental sustainability, …

… it’s a little hard to find in print, but we live in the information age and the ebook version is available at most … DNA sequence – sequences for the genes that code for the proteins that produce secondary metabolites. Do you … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

… DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of … molecules that bound inside the cells to tubulin, these proteins that allow the cells to divide. We found all sorts … that could afford to do all of the complex biology and production that we couldn’t do. So 2021, we have two drugs …

… welcome, Nadine. ALISON TAKEMURA: What is the big picture for you in your lab? NADINE ZIEMERT: Big picture, I want to … of cases, we still have to go through publications to get proteins, and their functions, and all that stuff. And … most. Because at the same time, you read a lot about the protein or the genes that you are analyzing. And then we’re …

… algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … and their roles in the environment, can unlock new avenues for bio-based products and bioenergy crop enhancement. The … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. …

… genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM … clusters across different species, which all encode the production of either the same or similar molecules. And then … with sequence similarity, either we just looked at which protein domains are in a gene cluster or we did sequence …