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… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … do engineering to improve the physical properties of a protein and make it easier to work with. But sometimes, what … with the co-factor is bound throughout the catalytic cycle. So that co-factor stays in the active site. And then …

… high-throughput sequencing and other resources at the JGI for projects of relevance to Department of Energy missions. … LanzaTech to rapidly engineer a Clostridium strain for the production of biofuels and bioproducts from low-cost gas feedstock. For …

… not good at that, you guys. I’m trying really hard just for you. And the JGI Comms team. But mostly you. Anyway…I’m … bind similar ligands. And so one of-- DAN: OK. The similar proteins are going to bind similar molecules. Yeah, OK. … when I started doing a lot of this natural product production within bacteria, they're great at it, but it …

… … DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … they can be things like biofilm formation. They can also be production, as we were mentioning before, of more complex … more structural diversity — so that one uses acyl carrier proteins as co-substrate. So the other ones they use CoA …

I think it must’ve been about 2001, maybe, and so it was before smartphones and before laptops and everything. And I … as well. A lot of them have looked at applications like biofuels. Dan Udwary: Sure. Kate Duncan: But from a natural … from sediment cores in Antarctica that have– some of being carbon-dated to kind of 15,000, 150,000 years ago. So this …

… … DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of … molecules that bound inside the cells to tubulin, these proteins that allow the cells to divide. We found all sorts … that could afford to do all of the complex biology and production that we couldn’t do. So 2021, we have two drugs …

… welcome, Nadine. ALISON TAKEMURA: What is the big picture for you in your lab? NADINE ZIEMERT: Big picture, I want to … of cases, we still have to go through publications to get proteins, and their functions, and all that stuff. And … secondary metabolite pathways as viewed through metagenome studies, and what more JGI and others can do to enable …

… it’s a little hard to find in print, but we live in the information age and the ebook version is available at most … DNA sequence – sequences for the genes that code for the proteins that produce secondary metabolites. Do you … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

… and collaborators have the right to produce manuscripts for publication and the responsibility for leading the efforts to do so, and JGI expects …   and/or make substantial intellectual contributions to the production of a manuscript, it is best practice to credit …

The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique … submits a proposal for consideration in the next review cycle. Initiate a full proposal by logging into the  EMSL … technologies available at JGI and EMSL such as DNA-SIP, Protein SIP, Flux Balance analysis with metabolites, Isotope …

… fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy and nutrient … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome interactions. The  insights derived are crucial for advancing the bioeconomy, environmental sustainability, …

… algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. … The … and nutrient acquisition. However, secondary metabolite production is often not fully realized under standard …