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… company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… wouldn’t say I was one of these people that wants to study oceanography and was fascinated by the oceans, though I’ve … inside them. And this was, I think it must’ve been about 2001, maybe, and so it was before smartphones and before … biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I …

… find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … We need treatments for humans. And it just so happens that bacteria make a lot of the kinds of molecules that humans … we’re going to add another 87,000. So that’s, what, a 20%, 30% increase?  Dan insert: It’s a 21.75% increase. ALISON …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … that are known to be sources of secondary metabolites, like sponges were a really common source for people to try to … come from bacteria that actually live within, say, the sponges or other things. And we know lots more about …

… Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … cousins. So we both went to Scripps [Institution of Oceanography in San Diego] together. And I worked for Brad …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into … talk to you in a couple of weeks at Scripps Institution of Oceanography. He got me into genomics of microbes, …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … lot of the natural products field is based on, you know, in bacterial investigations. You’ve spent your whole career as … on microbiomes they only talk about the bacteria. My god! 30% of our gut microbes are fungi. It’s really frustrating …

… on identifying and characterizing haloperoxidases from bacteria. And with Christian, I started getting a little bit … Great Salt Lake, which is a hypersaline terminal lake about 30 minutes away from campus. And we’re finding some really, … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening since 2005. … T ., Klenk H. P., Kyrpides N. C. 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … are very stable interactions that have been evolving for 300 million years, that could be a reasonable number if you …

… have spread quietly throughout our planet. From the deepest ocean floors to Antarctic valleys, these organisms have … while simultaneously decoding the biological meaning hidden within millions of genes? Fostering a Deeper … entirely new capabilities through partnerships with bacterial symbionts, and how others revolutionized their …