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… for the US Department of Energy Joint Genome Institute, or JGI. JGI is a DOE Office of Science User Facility located at … and that we might just kind of happen across them in our food. That’s crazy!  DAN: Yeah, just like the geosmin – … to us and understanding all of that I think is what really drives me to understand what’s going on with natural …

… the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … of public genomic data. Science  363(6425):350-352 Harrington LB, et al (2018) Programmed DNA destruction by miniature …

… needed to prepare and ship samples for sequencing by the JGI.  Additionally it includes instructions on accessing … your Project Manager or jgi[email protected] . … 1) Review JGI sample QC requirements and protocols Obtaining … in the shipping approval email (please avoid U.S. federal holidays). We recommend shipping your samples on dry ice. …

… most secondary metabolism pathways now, but there’s still almost certainly unusual things that we don’t recognize, … or secondary metabolism, has been … not dominated by, but driven by drug discovery. We know that many natural product … have that goal. That’s not as much our goal here at the JGI – we are not a medicinally focused organization. And so, …

Anomaly” first described by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial … lab is therefore focused on the application of  function-driven single-cell genomics . Here, single cells are … for new branches on the tree of life. Science. 346:698-9 (2014). Ivanova N.N., Schwientek P., Tripp H.J., Rinke C., …

… school. And one of the things that I noticed is all the food that the students got was coming from other countries, … when I first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins … actually, everything is funding, right, isn’t it? I thank JGI for sequencing a lot of fungi. But the thing with them – …

… state of things, and what we’re hoping to accomplish at JGI in this area. If this series of podcast episodes has … be the software after it’s been installed on your hard drive. And then the protein would be the software actually … have been carried through exactly the way it was, which it almost certainly hasn’t, then we’ve – we have no ability to …

… describe. [ Go here to learn more about Tiny Earth and the JGI’s role in the project by watching Amanda Hurley’s … I met him when we worked together at the late great Warp Drive Bio, a biotech startup where we did genome mining … the pathogen comes along. So this pathogen preys on the food source for the ants. And the ants, they have a symbiont …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … contribute to ecosystem functions, the Program helps drive innovations that could advance our understanding of … viral populations. Enabling microbiome data science:  The JGI supports microbiome data science by enabling comparative …

… research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … metagenomics. Nature Reviews Microbiology volume 20, 721–736 JC Villada, F Schulz (2022) The endosymbiotic box of … Scientific reports. 5 (1), 1-10 Schulz et al. (2014) Life in an unusual intracellular niche: a bacterial …

… and at Scripps where I first met Dan. I think you were almost finishing when I was getting there but–  DAN: Yeah. I … do when you’re exploring your systems. Because I think the JGI has a little bit of a different approach. We don’t … It gardens the fungus in order to make parts of it for food.  And then some of our more recent work, what we’ve …

… to the California gold rush. And we’ll talk about a new JGI paper that’s just come out where I got the chance to do … to find are medicines. Medicine has always been the main driver for secondary metabolism drug discovery. Because we … universal in bacteria. There are a few exceptions, but almost always the genes are clustered. Like I said, most of …