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… was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … So a lot of my work is as focused on insects As a host, and a little bit of my newer work is focused on … you for that insight. DAN: So I suppose, coming up with large collections of new microbes and new activities, feeds …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … a thioesterase. And so that thioesterase at the end of this large multimodular protein allows for release from the DNA, … fun that we've started that is a different subject is from microbes to medicine labs. So this is-- we've been working …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening since 2005. … E. A., Kyrpides N. C., Woyke T . Giant virus diversity and host interactions through global metagenomics.” Nature …

… find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … regions of secondary metabolism should be. That’s still largely homology based, but then you’re using kind of a … metabolism genes don’t look like the genes in their host. And so, sometimes those kinds of things get lost in …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … derivatives of natural products.  ALISON: Like such a large diversity can have similar effects, I think is also … at naturalprodcast.com Special thanks, as always, to my co-host, Alison Takemura. <woohoo> If you like Alison, and want …

… of background. My name is Dan Udwary. I – as well as my co-host, Alison Takemura, whose voice you’ll hear in a minute – … was adjacent to what I worked on, but my experience of how microbes are interacting in the environment like, like my … So taxol is a natural product, a cancer drug. It was the largest selling drug back in the early 2000s for cancer. You …

… of thousands of new viral genomes and their predicted hosts (Nature 2016, Science 2017, Nature Microbiology 2018), … and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in the group include … as well as the development of novel methods to enable large-scale comparative analysis, mining and visualization …

Science Program (CSP) provides the scientific community at large with access to high-throughput sequencing, synthesis, … Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that leverage a … annotations, and analyses available to the community at large. In most cases where the JGI provides more customized …

… worked for the best part of 20 years on products that were largely in commercialization, I thought it’d be great to … being used to essentially domesticate a range of different host organisms through introducing “landing pads” that you … But they really span our core science programs which are microbes, and fungi, and algae plants, synthetic biology. …

And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … together to make small peptides. Those are fun, because the host organism can use whatever amino acids it has access to, … at naturalprodcast.com Special thanks, as always, to my co-host, Alison Takemura. <woohoo> If you like Alison, and want …

… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where … naturalprodcast.com . Special thanks, as always, to my co-host Alison Takemura. If you like Alison, you want to hear …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use … (5), 255-255 Schulz et al. (2020) Giant virus diversity and host interactions through global metagenomics. Nature. 578 …