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Biology is currently experiencing a revolution brought on by rapid developments in … and comparative analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the … Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and host interactions through global …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … as what we initiated our search around. And so we found examples of those, and then looked for NRPSs nearby, …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … products systems. This conversation came about because he challenged me on my use of the term “secondary metabolism.” … work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can …

Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it going?  DAN: Good. How are you?  MARCY: Am fine. I live in a … about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … in the same place on the chromosome then you’ve definitely found a biosynthetic gene cluster.  And so those are really …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … sequencing if you were rich enough. [CHUCKLES] And once you found a little piece of something that looked like it was a …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … been involved with the AntiSMASH and MIBiG projects. And I found her review in natural product reports on the evolution … they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are …

… for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … AARON PURI: Yeah. Yeah. So the more recent one that they found, which has a lot more structural diversity — so that …

Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … a focus on addressing critical energy and environmental challenges. Through innovative research in synthetic … Rapid Metabolic Engineering: Metabolic engineering traditionally utilizes a stepwise approach for strain …

… … DAN: You’re listening to the US. .Department of Energy Joint Genome … that people were looking for in the soil kept getting found over and over again. So we call this the “rediscovery … So, one of those is Acinetibacter . This is a genus of bacteria that’s really popped up at funding agencies and the …

… supposed to be orthogonal. And then we much to our chagrin found that they had the same conserved polyketide synthase … in the marine ecosystems and marine actinomycetes and cyanobacteria. And we thought we could also– let’s see what caves … –what you need is what JGI is providing, which is a giant warehouse full of microbial sequences. So let’s say …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … like this pathway encodes a polyene chemical”. And they found one, and they solved a chemical structure. But they, … Initially, my group really focused on marine actinobacteria. Then we moved into marine proteobacteria. Not a …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … went on the hunt for other similar bacteria or fungi, and found them. And that’s why penicillin saved millions of …