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… the amazing John Faulkner’s work, who passed away about 17 years ago now. It looked really interesting. He was … them. And so there’s a long history. There’s, I think, 60 years of history now of people looking at sponge chemistry … for the last 10 years in this area. ALISON:  Just a clarifying question, like small molecule versus peptide. It’s the …

Developed in 2017, the PDT was established in part to help better-connect … with the JGI and Berkeley Lab Biosciences Area to quantify atmospheric gas mitigation properties of multiple rice …

… try to understand the biosynthetic pathway or to help identify the compound that they were interested in. But nowadays, … on the backs of people who’ve done a lot of work over the years. We have a pretty good idea of what the different … is another community effort that’s been built up over the years and is really strong for finding lots of different …

… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … drug conjugates, abbreviated as “ADC”, was approved in the year 2000, and utilize the enediyne as the payload. We call … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t …

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… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, you’re like, famous. Dan: Famous? … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole …

… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very … how much blood, sweat, and tears went into trying to identify that you had the right cluster before you sent it out for …

… was at the Broad Institute in Cambridge, Mass. for a couple years before joining Warp Drive. And what kind of pushed me … time. And yeah, I mean, that was let’s see, maybe 5,6,7 years ago, and I’ve – I haven’t looked back. ALISON: So you … to be involved in signaling. We’re not perfect at identifying what these pathways are yet. So there’s still a lot to …

It was actually when I was traveling at the end of first year University. Quite a lot of people in Europe do this … an undergraduate in chemistry. Now when I was in fourth year, we had a choice to do an integrated master’s program … like. I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. …

The publications resulting from such efforts should specify the collaborative nature of the project, and authorship … products produced through all user projects accepted FY22 and later. … Read about our policy on research data and … products produced through all user projects accepted before FY22. … Publication Policy … Data Management at the JGI … …

… of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary metabolism … that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve … time. So they had actually sequenced the genome a number of years earlier as one of the first Streptomyces genomes that …