Search

… was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … there’s hot spots of really potent antibiotics. There’s cold spots where the pathogens are taking over and …

… and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to … This process enables our users to explore the genetic makeup of microbial communities, shedding light on … implementation of prokaryotic systematics across cultured microbes and recovered population genomes using Average …

… products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of experimental samples, including organisms (e.g. microbes, fungi, plant), media in which they grow, as well as different types of environments (e.g. soil, lake).  A wide range of metabolites are identified using …

… in the feed, the secondary metabolism field has been dominated for … well, as long as I can remember, by … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And they have all …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … products field, or secondary metabolism, has been … not dominated by, but driven by drug discovery. We know that …

… especially for these primer episodes, if you want to dive deeper on all this at http://naturalprodcast.com . And then … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … want to explain that to someone who doesn’t know much about genetics or anything else, science wise maybe, what genome …

… product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber to be a … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … soil. But we also have, in collaboration with other people, lake sediments. We have microbiomes from different …

… technology to help access complicated natural product gene clusters, and we’re all really excited about that, and … that we are working on into perspective in the field in general. So what has happened in the past two decades is … total, and different people have different numbers, but in general, an authoritative number for total number of natural …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … firstly set up a baseline process. And then really dig deeper into both aspects of the strain, as well as the … But they really span our core science programs which are microbes, and fungi, and algae plants, synthetic biology. …

… see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … peptides”. And, you know, we don’t need to get too deep into the chemistry but let’s talk about that compound … really need to know how they’re made. You need to bring the genes into the lab, and you need to manipulate them in the …

… the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve … that really looked promising. We found that there were new genera, these basic taxonomic group called the genus. We …

… techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … single cell approaches. This includes linking strain-level genetic variation to ecological niche adaptations.  Single …