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I got the chance to do genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As … and do some really complicated carbon skeleton rearrangements, chemistry that we probably don’t [need to] get … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

… with recent computational technology advances in management, processing and visualization of “big data,” and … of the functional dark matter as well as the development of novel methods to enable large-scale comparative analysis, … Acids Res.  45(D1):D457-D465. Paez-Espino, D. et al. (2016) Uncovering Earth’s virome.  Nature   536:425-30 Kyrpides NC. …

Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … regulation, and noncoding RNAs in microbiomes. The insights from this work have the potential to drive innovations in … most pressing challenges. … Exploration of phylogenomic novelty: Advances in metagenomic sequencing, assembly and …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — … imaging, and other data from EcoFAB systems can provide novel insights into the impact of microbial symbionts and …

… data and serving them to users via the Integrated Microbial Genomes & Microbiomes (IMG/M) system. Research Team    … The … of the Integrated Microbial Genomes (IMG) data management system … As part of this project, pairwise average … species specificity of single cells and genomes extracted from metagenomes, and also as a metric for quality control …

… for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will work with … … A primary purpose of this project is to bring educators from a broad range of disciplines up-to-speed with some of … public datasets.  … The Integrated Microbial Genomes & Microbiomes system ( IMG/M ) supports the annotation, …

… leads to identification of biosynthetic gene clusters for novel secondary metabolites for multiple applications.       … methods in the past decade, researchers have uncovered genomes for just a small fraction of Earth’s microbial … November 9, 2020 in  Nature Biotechnology . Known as the GEM (Genomes from Earth’s Microbiomes) catalog, this work …

… solutions in energy, agriculture and ecosystem management. … The Microbial Program focuses on using advanced … in particular to study inter-organismal interactions. Novel approaches are being explored to predict microbial … catalog : Beyond minimal draft and improved draft microbial genomes the program offers single-cell sequencing, …

… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s been … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

…     Our homepage video includes external footage from:  University of Delaware Laura.Selbmann©PNRA. All the … achieving a predictive understanding of complex biological, earth, and environmental systems for energy and … Understand the assembly, function, and the behavior of microbiomes and manipulate them to facilitate microbial …

… is really another example. This sort of carbon arrangement, which we know as a structure of a natural product, … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly …