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The focus of this group, in recent years, has been to bring generalizable technologies to bacteria, yeasts and algae previously with little to no genetic tools …

Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … combinatorial construct variations. These constructs are subsequently synthesized and tested for their ability to …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … – it’s terrible – it’s mostly in Africa. You get severe diarrhea, and if you aren’t treated, people die. But why this … And it’s actually been pretty easy to breed plants with resistance to pathogenic fungi that invade or colonize their …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … here at JGI. So within ABC, we have something in the neighborhood of 400,000, last I checked, biosynthetic gene …

… things, because a lot of what we do at JGI in terms of the sequencing that we do is very people-disconnected, and … replicate that in the lab because an aqueous extract with heat is going to yield a different composition than a cold … want to get your hands on more natural products, but perhaps the idea of running off into the forest and …

Biology is currently experiencing a revolution brought on by rapid developments in … other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … metagenomic map of urban microbiomes and antimicrobial resistance. Cell . 184(13):3376-3393 Almeida A, et al. …

The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the …

To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell …

… live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … is nowadays, but traditionally, somewhere in the neighborhood of 60 to 70% of all of the medicines that we use are … Was it because were you already experiencing antibiotic resistance at that point?  DAN: Yeah, I’m glad you asked. …

Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I should ask, you … before– or kind of around about when the first genome sequencing was done. But natural products– marine natural … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… … DAN: You’re listening to the US. .Department of Energy Joint Genome … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … is, is directly that in the face of growing antibiotic resistance, so we’re looking in soil that’s extremely …