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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … this? NADINE ZIEMERT: It wasn’t that long ago, but maybe 2006, 2007, or something like that. And we actually found the …

… in this hypersaline environment, which can range from 8% to 28% salinity. We have toxic metals, so these concentrations … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… within the realm of education. … Through the Berkeley Lab K-12 program, the JGI collaborates with Biotech Partners to …

Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed (or about one per student) Seven … et. al.  2023 . Microbiology Resource Announcements. 2023 12 (10), e00548-23 Whole genome sequence of the denitrifying …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …

… access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum … signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. Methylotroph …

… 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … the issues is in order to make the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to change the amide …