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… and welcome to Episode 6 of Natural Prodcast. What you’re going to get here is the very first episode we recorded. … Am I ready? I don’t know. I don’t know. We’ll see. Let’s find out.  DAN: All right, so the first person that I wanted … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their …

Medema: It was quite uncertain whether that meeting was going to happen in the first place. And yet everything got … the time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused … all based on antiSMASH results. And so if you want to do deeper analysis on things, then you’re staying in the “BiG” …

… to some cool papers in the show notes, which you can always find at naturalprodcast.com or through the JGI website at … it was not appropriate. DAN UDWARY: Yeah. No, that was not going to fly. So yeah. So we’re giving him a second chance … have to do a 10,000-fold dilution to plate that out. The deeper you go in the cave, the less dilution. You can be …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … to link metabolic activity with gene expression, providing deeper insights into functional genomics. A key focus is … and a list of scored metabolite matches associated with genes.  … Metabolomics Offerings & Capabilities … …

… things that we don’t recognize, because the only way to find things is by comparison. We’ll talk about that when we … It’s an evolution of primary metabolism. So a lot of the genes and the DNA that’s used for secondary metabolism, they … because you have all these pockmarks. But yeah, what’s going on?  DAN: All right. So this is a photograph of the …

… on my self-imposed schedule. So, we’ll have to see if I’m going to slip a day on releasing it into the feeds, but I’m … and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … for the first time getting excited about this. And so you find these clusters. And one can think about when we talk …

… you do it. So, I don't know how we start out. Where are we going to go from here? JACKIE: Well, how about you just give … in enzymes to do some of the reactions that chemists find really challenging. So that balance is really fun. … coelicolor versus Streptomyces lividans. They both have the genes. The genes are pretty much 100% identical. We don't …

This is one of my favorite interviews so far – you’re going to hear how passionate and enthusiastic Ben is about … the audio, head over to naturalprodcast.com, where you’ll find transcripts and show notes for every episode we put … natural products or biosynthetic chemistry and want to dive deep on the topic, or just want to take a look at several …

… and natural products from the Great Salt Lake, and you’re going to learn, like me, what a “haboob” is. Then, we switch … terminal lake about 30 minutes away from campus. And we’re finding some really, really interesting compounds, and we’re … organisms actually have quite a few antibiotic-resistant genes in there. And so we’re trying to use those as …

… climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program … evolution. It also utilizes advanced tools, including deep learning algorithms for gene annotation and protein … differences in plants and will accelerate gene discovery. BrachyPan on Phytozome (see Brachypodium Resources below) …

… depending on which term you prefer. In this episode we’re going to finish up by talking about the modern, post-golden … the bacterial side of the field, and it’s a little hard to find in print, but we live in the information age and the … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary …

… we derived from meta-genome sequences. As always, you’ll find transcripts and show notes with links to lots of other … especially for these primer episodes, if you want to dive deeper on all this at http://naturalprodcast.com . And then … home, not back at school. So, yeah. So there’s been a lot going on. But Natural Prodcast needs to come back, right? …