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The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work encompasses bacteria, archaea, and … to assess microbial activity across ecosystems.  By studying microbial communities and their interactions, the …

… about natural products and the science and scientists of secondary metabolism. Welcome back for our second season of … like, and then you could characterize it. The classical study that demonstrated this is Challis et al, Chemistry and … if an order is uncultured (blue; represented only by metagenome-assembled genomes or MAGs) or cultured (gray; …

… … Dan Udwary: Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk … I wouldn’t say I was one of these people that wants to study oceanography and was fascinated by the oceans, though … a subset of molecules that will fly on an analytical instrument and be detected. Dan Udwary: You’re making me so …

… about natural products and the science and scientists of secondary metabolism. Welcome back. This will be episode 12 of … ALISON TAKEMURA: So Nadine, what got you interested in studying natural products? NADINE ZIEMERT: Like almost … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot …

Prodcast,” a podcast about the science and scientists of secondary metabolism.  DAN: Hi, again. This is Dan, and you’re … secrete a lot more things than people do…? Although I don’t study people so maybe I’m wrong. But yeah, I mean, because I … them as very small fungi. And this came from a growth on a cow’s cheek. Historically, before antibiotics were common, …

Prodcast,” a podcast about the science and scientists of secondary metabolism.  DAN: Hello, and welcome back for Episode … the production of the natural product. So that was my PhD study, and then towards the end of my PhD study, then … And we are still asking the fundamental question, how is Mother Nature making natural products? But we are no longer …

… about natural products and the science and scientists of secondary metabolism. Hey everybody, this is Dan with episode … technologies or uses or applications– are the evolutionary nature of these compounds. At the end of the day, all the … evolutionary forces are shaping each part of the metabolic network in each specific organism. Really, what matters is …

… about natural products and the science and scientists of secondary metabolism. Hey there, and welcome back to Natural … what was this bacterium, and why did your group want to study it? Marnix Medema: You mean the PhD project that I … primer episode, we talked about genome mining through some metagenome associated genomes. And yes, antiSMASH is …

Prodcast,” a podcast about the science and scientists of secondary metabolism.  DAN: Hi again, and welcome to Episode 6 … sending signals. But really unpacking that complicated network of chemistry and communication is what I’m really … we have no idea what natural products are doing in nature. And it’s a really difficult thing to unpack …

… curator there, with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and … And for the audience, ethnobotany is the scientific study of the ways that people interact with plants, whether it’s for plants to make clothing, or musical instruments, or food, or medicine, which was really where my …

… … DAN: Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it going?  DAN: Good. … now?  MARCY: Sure. So my lab has really converged on the study of host-microbe chemistry. And the interactions– As … Marcy. So I was wondering, how did you get interested in studying natural products?  MARCY: That is a great question …

… … DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the … kept looking for open jobs that said, we want a chemist to study the ocean. And I didn’t find a single job … FENICAL: Yeah. That’s the massive question in cancer chemotherapy, is how do you find a target in a cancer cell that …