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… complicated enzymatic conversions. The last couple of steps and the first couple of steps of aflatoxin … The sequence tells you a lot, but it doesn’t tell you nearly everything. What I think a lot of people hope for is … having a baseball glove or some kind of glove, and you’re comparing different gloves. And then if you get enough …

… computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … and reconstruct metabolic properties encoded within those genomes. Our aim is to more fully capture microbial and … on the assembly of metagenomic sequence data into microbial genomes, which is of fundamental value to improving our …

… reports and tracking statuses.  Please follow the steps outlined below. Click the drop-downs to learn more … Project Manager (PM) a list of organism names (or for metagenomes, sample names).  Need help naming your organisms? …

… us that we want to talk a little bit about. It’s sort of early stages. But I think that is emblematic of some of the … beginning in 1950– or really 1940– was based on microbial cultivation, microbial fermentation in huge quantities, … phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So Salinispora , …

… Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … catalog of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom … environments. Integrating metatranscriptomes and metagenomes can, for instance, deepens our understanding of …

… Dan, when you were supposed to visit us in the Netherlands early this summer, then it was– well, I think the day your … and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … makes the data usable for people who want to do the next steps in science. Alison Takemura: And what does MIBiG stand …

… for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will work with … Joint Genome Institute, builds upon thousands of microbial genomes that have been sequenced by the JGI though not … development and adoption of classroom modules Currently 206 genomes have been selected with 11 published manuscripts …

… metabolism and secondary metabolism, and we talk about the early history of the field. Then, in the third episode, … pilgrims if they’re up there? I don’t know.  DAN: Maybe early colonists? Yeah. ALISON: Wow, that’s nuts. I had not … a cancer drug. It was the largest selling drug back in the early 2000s for cancer. You know, a billion dollar drug. But …

… and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the … culture collections to produce hundreds of diverse algal genomes, which will be made accessible through the PhycoCosm … for microbial eukaryotes, build fungal and algal pangenomes, and integrate multi-omics tools to enhance …

… to disease-resistance that could prove fruitful for saving Citrus from greening disease. You’ve probably never heard of … Poncirus trifoliata , it’s an evolutionary cousin of the  Citrus genus, which gives us lemons, kumquats, limes, pomelos, mandarins, sweet oranges, and more. Unlike citrus, trifoliate orange ripens only bitter, intensely sour …

… Brian went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of … at Scripps, I guess, 22 years ago. And it’s over 130 steps to make everninomicin. DAN UDWARY: Yeah, one of those. …

… to a particular producing organism in the context of a clearly defined ecological interaction. So it’s not central … bit more intuition about how you go from the expansion to comparing to the database. Is it like, let’s say I’m drawing … behind these stories, because what we want to learn are lessons that can be translated into applications, not the …