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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And …

… and materials. The proposal submission deadline is March 31, 2026 .  … the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the … with EMSL, APS, BioSANS typically has an acceptance rate of 12 to 15%, mainly due to resource limitations with our …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… Right, because they’re so reactive. BEN: …going back to the 1950s. But the structure of which was not known until the … right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… phyl. nov .”  ISME Communications , Volume 5 Issue 1. Wittmers, F. et al (2024) “ Non-photosynthetic lineages … meta-omic conclusions .”  Nature Communications Volume 15 Article 9873. Buscaglia, M. et all (2024) “ Adaptation … marine ecosystems .”  The ISME Journal , Volume 18 Issue 1. Pitot, T.M., et al (2024) “ Conservative …

… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., … across Earth’s biomes. Nature Microbiology. 4, 1895–1906. https://doi.org/10.1038/s41564-019-0510-x Roux, S. et …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum …

… people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … the issues is in order to make the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 …