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… the traditional sort of academic path or even just the scientific path of “I know exactly what I’m going to do and I’m … so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … in the field, these glacial bacteria grow slow and it’s not 100% clear that we know what their biological activities …

… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. ALISON TAKEMURA: 2010, OK. You’re a young faculty. …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … try to understand the biosynthetic pathway or to help identify the compound that they were interested in. But …

… convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … we couldn’t get a lot of chemical compound from a beautiful coral reef animal. We didn’t want to collect all of … course using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …

… people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … them back to us and we'll do a PCR analysis to sequence the 16S and things like that to figure out what they actually …

… the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the proposal. Also, once awarded, users have 12 months before they need to activate their project. … end of an active proposal in order to continue access in 12-month increments.  At the JGI, a typical proposal is …

… first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins worked … do you check if they’re there? Like we always talk about 16S for bacteria, but we don’t talk about it so easily with … today who said “Oh, the ITS which we thought would identify to species”… he’s now found that some fungi have …

… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …

… Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ … biology and genomics. Myco-Ed aims to integrate real scientific contributions/discoveries into undergraduate teaching …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… 313.081 179% 2,208 2,064 95.4% Q2 2026 175 243.806 139% 2,160 2,112 99.8% Q3 2026 175     2,164     Q4 2026 175     2,208     … % Goal   FY 2025 Total   700.0 1,144.186 163% 8,585 8,640 100.6% Q1 2025 175 190.304 109% 2,164 2,136 98.7% Q2 2025 …