Search

… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on … microbiome field, many people had just been looking at like 16S taxonomic profiles of these communities looking at who …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … this is Challis et al, Chemistry and Biology, 2000, 211-224, 7:3 And so, you can then make predictions about … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … in the field, these glacial bacteria grow slow and it’s not 100% clear that we know what their biological activities … call this the needle in the Haystack. Because if we have 10,000 features which one do we look at because we are a …

… recruit new talent for biosciences.  Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed … Xenorhabdus cabanillasii DSM17905, Xenorhabdus ehlersii DSM16337, Xenorhabdus japonica DSM16522 R Robertson, et. al.  2023 . Microbiology Resource Announcements. 2023 12 (10), e00548-23 Whole genome sequence of the denitrifying …

And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and …

… components. Science, 356 (6333), 82-85 Schulz et al. (2016) A Rickettsiales symbiont of amoebae with ancient … in the Gammaproteobacteria. Scientific reports. 5 (1), 1-10 Schulz et al. (2014) Life in an unusual intracellular … infecting the nucleus of amoebae. The ISME Journal. 8 (8), 1634-1644 … Publications … For further details, please reach …

Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ …

… convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … of the molecules in ecology. And that took another 10 years at least. But I had several students. And I worked … course using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …

… first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins worked … do you check if they’re there? Like we always talk about 16S for bacteria, but we don’t talk about it so easily with … mostly coming out of China and India, very cheap for $100-$200. But you have so many contigs. This is a problem …

So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … we have here – all of them were collected before 2016, before that true enforcement of the Nagoya protocol. And …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …