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    Data yielded from RIViT-seq increased the number of sigma factor-gene pairs confirmed in Streptomyces coelicolor from 209 to 399. Here, grey arrows denote previously known regulation and red arrows are regulation identified by RIViT-seq; orange nodes mark sigma factors while gray nodes mark other genes. (Otani, H., Mouncey, N.J. Nat Commun 13, 3502 (2022). https://doi.org/10.1038/s41467-022-31191-w)
    Streamlining Regulon Identification in Bacteria
    Regulons are a group of genes that can be turned on or off by the same regulatory protein. RIViT-seq technology could speed up associating transcription factors with their target genes.

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    (PXFuel)
    Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
    In a special issue of the journal Synthetic Biology, JGI scientific users share how they’ve worked with the JGI DNA Synthesis Science Program and what they’ve discovered through their collaborations.

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    A genetic element that generates targeted mutations, called diversity-generating retroelements (DGRs), are found in viruses, as well as bacteria and archaea. Most DGRs found in viruses appear to be in their tail fibers. These tail fibers – signified in the cartoon by the blue virus’ downward pointing ‘arms’— allow the virus to attach to one cell type (red), but not the other (purple). DGRs mutate these ‘arms,’ giving the virus opportunities to switch to different prey, like the purple cell. (Courtesy of Blair Paul)
    A Natural Mechanism Can Turbocharge Viral Evolution
    A team has discovered that diversity generating retroelements (DGRs) are not only widespread, but also surprisingly active. In viruses, DGRs appear to generate diversity quickly, allowing these viruses to target new microbial prey.

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    Photograph of a stream of diatoms beneath Arctic sea ice.
    Polar Phytoplankton Need Zinc to Cope with the Cold
    As part of a long-term collaboration with the JGI Algal Program, researchers studying function and activity of phytoplankton genes in polar waters have found that these algae rely on dissolved zinc to photosynthesize.

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    This data image shows the monthly average sea surface temperature for May 2015. Between 2013 and 2016, a large mass of unusually warm ocean water--nicknamed the blob--dominated the North Pacific, indicated here by red, pink, and yellow colors signifying temperatures as much as three degrees Celsius (five degrees Fahrenheit) higher than average. Data are from the NASA Multi-scale Ultra-high Resolution Sea Surface Temperature (MUR SST) Analysis product. (Courtesy NASA Physical Oceanography Distributed Active Archive Center)
    When “The Blob” Made It Hotter Under the Water
    Researchers tracked the impact of a large-scale heatwave event in the ocean known as “The Blob” as part of an approved proposal through the Community Science Program.

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    A plantation of poplar trees. (David Gilbert)
    Genome Insider podcast: THE Bioenergy Tree
    The US Department of Energy’s favorite tree is poplar. In this episode, hear from ORNL scientists who have uncovered remarkable genetic secrets that bring us closer to making poplar an economical and sustainable source of energy and materials.

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    HPCwire Editor's Choice Award (logo crop) for Best Use of HPC in the Life Sciences
    JGI Part of Berkeley Lab Team Awarded Best Use of HPC in Life Sciences
    The HPCwire Editors Choice Award for Best Use of HPC in Life Sciences went to the Berkeley Lab team comprised of JGI and ExaBiome Project team, supported by the DOE Exascale Computing Project for MetaHipMer, an end-to-end genome assembler that supports “an unprecedented assembly of environmental microbiomes.”

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    With a common set of "baseline metadata," JGI users can more easily access public data sets. (Steve Wilson)
    A User-Centered Approach to Accessing JGI Data
    Reflecting a structural shift in data access, the JGI Data Portal offers a way for users to more easily access public data sets through a common set of metadata.

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    Phytozome portal collage
    A More Intuitive Phytozome Interface
    Phytozome v13 now hosts upwards of 250 plant genomes and provides users with the genome browsers, gene pages, search, BLAST and BioMart data warehouse interfaces they have come to rely on, with a more intuitive interface.

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    screencap from Amundson and Wilkins subsurface microbiome video
    Digging into Microbial Ecosystems Deep Underground
    JGI users and microbiome researchers at Colorado State University have many questions about the microbial communities deep underground, including the role viral infection may play in other natural ecosystems.

    Read more

    Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical output due to growth and viability constraints. Cell extracts provide an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at volumetric productivities greater than the source strains. (Blake Rasor)
    Boosting Small Molecule Production in Super “Soup”
    Researchers supported through the Emerging Technologies Opportunity Program describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system.

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    These bright green spots are fluorescently labelled bacteria from soil collected from the surface of plant roots. For reference, the scale bar at bottom right is 10 micrometers long. (Rhona Stuart)
    A Powerful Technique to Study Microbes, Now Easier
    In JGI's Genome Insider podcast: LLNL biologist Jennifer Pett-Ridge collaborated with JGI scientists through the Emerging Technologies Opportunity Program to semi-automate experiments that measure microbial activity in soil.

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    A view of the mangroves from which the giant bacteria were sampled in Guadeloupe. (Hugo Bret)
    Giant Bacteria Found in Guadeloupe Mangroves Challenge Traditional Concepts
    Harnessing JGI and Berkeley Lab resources, researchers characterized a giant - 5,000 times bigger than most bacteria - filamentous bacterium discovered in the Caribbean mangroves.

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    In their approved proposal, Frederick Colwell of Oregon State University and colleagues are interested in the microbial communities that live on Alaska’s glacially dominated Copper River Delta. They’re looking at how the microbes in these high latitude wetlands, such as the Copper River Delta wetland pond shown here, cycle carbon. (Courtesy of Rick Colwell)
    Monitoring Inter-Organism Interactions Within Ecosystems
    Many of the proposals approved through JGI's annual Community Science Program call focus on harnessing genomics to developing sustainable resources for biofuels and bioproducts.

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    Coloring the water, the algae Phaeocystis blooms off the side of the sampling vessel, Polarstern, in the temperate region of the North Atlantic. (Katrin Schmidt)
    Climate Change Threatens Base of Polar Oceans’ Bountiful Food Webs
    As warm-adapted microbes edge polewards, they’d oust resident tiny algae. It's a trend that threatens to destabilize the delicate marine food web and change the oceans as we know them.

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News & Publications
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July 15, 2011

Dry rot (Serpula) genome project on WalesOnline

WELSH scientists are looking at harnessing the power of the virulent fungus which causes dry rot to help make biofuels of the future. Closer examination of the damaging fungus Serpula lacrymans as part of an international project led by Swansea University could also hold the key to protecting buildings from dry rot. Read more at… [Read More]

July 15, 2011

Serpula genome project on MyCor Fungal Web Genomics

The other good news of this Bastille Day: our paper on the Serpula lacrymans genome is reported online July 14 in Science Express. The Domestic Dry Rot (Serpula lacrymans, Basidiomycete, Coniophoraceae) comprises two subgroups, S. lacrymans varshastensis, found in montane conifer forests in the Himalayan foothills, and S. lacrymans var lacrymans, cause of building dry rot, which diverged in historic time [Kauserud et al. (2007) Mol. Ecol.16: 3350-3360].  Read… [Read More]

July 13, 2011

DOE JGI’s role in national quest for cellulosic biofuels in the New York Times

The rumen is like a huge bathtub, he said, holding about 50 large soda bottles’ worth of fluid redolent with bacteria. Relying on these symbiotic microbes, cows eat up to 150 pounds of grass a day, a food inedible to most animals, including humans. Hess was after those microbial secrets, and the placid heifer was… [Read More]

July 11, 2011

Mycosphaerella genome project in Capital Press

Septoria typically infects young seedlings that have recently emerged, creating lesions, and spreading to the higher leaves. It can affect yield and quality, Goodwin said. Control methods are typically fungicide sprays, he noted. Igor Grigoriev, of the U.S. Department of Energy’s Joint Genome Institute in Walnut Creek, Calif., has been sequencing the genomes of other… [Read More]

July 9, 2011

Wallaby Yields Insight Into Limiting Methane

Research published in the June 30 edition of Science Express features an analysis of the microbial content of the Tammar wallaby gut, which may inform strategies for diminishing greenhouse gas emissions from other ruminants. Selected as a sequencing target by the DOE JGI’s Community Sequencing Program (CSP) in 2007, scientists had became interested in these mini… [Read More]

July 8, 2011

DOE JGI/JBEI collaboration in DomesticFuels.com

Researchers from the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) and the Joint BioEnergy Institute (JBEI) at DOE’s Lawrence Berkeley National Laboratory are trying to discover salt-loving organisms that may be more efficient in treating biomass and improve sugar yield for biofuel production. The class of solvents known as ionic liquids, are liquid forms of salt that… [Read More]

July 6, 2011

UCLA microbiologists find energy-efficient structures in archaeon

a type of Archaea known as Methanosprillum hungatei contains incredibly efficient energy-storage structures. The findings are published in the July 5 issue of the journal Environmental Microbiology. M. hungatei is of considerable environmental significance because of its unique ability to form symbiotic relationships with syntrophic bacteria to break down organic matter and produce methane gas. Yet while their important role in… [Read More]

July 1, 2011

DOE JGI/JBEI collaboration in Green Car Congress

Such salt-tolerant enzymes, particularly cellulases, offer significant advantages for industrial utility over conventional enzymes, they said. The group plans to expand this research to develop a full complement of enzymes that is tailored for the ionic liquid process technology with the goal of demonstrating a complete biomass-to-sugar process, one they hope can enable the commercial… [Read More]

June 17, 2011

GreenCut algorithm in Crop Biotech Update

Grossman and colleagues revealed that many of the GreenCut proteins are also present in ancient cyanobacteria, red algae, and diatoms. Further assessment of these proteins is expected to bring more discoveries about their functions in photosynthetic cells, and how the photosynthetic cells might be adapted to survive various environmental conditions. Read more in ISAAA’s Crop… [Read More]

June 17, 2011

GreenCut algorithm in e! Science News

Using advanced computational tools to analyze the genomes of 28 different plants and photosynthetic organisms, Grossman and his colleagues at the University of California in Los Angeles and the Joint Genome Institute of the Department of Energy were able to identify 597 proteins encoded on plant and green algal genomes, but that are not present… [Read More]
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